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Title: Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster

Abstract

The spectrum and frequency of chromosomal aberrations in the somatic cells of III instar larvae of Drosophila melanogaster mutator line were studied using three of its derivatives (sbt, if, and w/sup a/) and line w as control. It has been demonstrated that the frequency of anaphases with bridges and acentric fragments increases in the neuroblast of flies of the mutator line as well as in the neuroblasts of the larvae of the lines sbt, if, and w/sup a/. The metaphase analysis revealed that the mutator line and its derivatives are characterized by higher frequencies of chromosomal aberrations as compared to the control. Chromatid breaks are predominant type of rearrangements. These results, suggest probably presence of the specific mutator factor or factors in the line studied, affecting chromosomal structure and, possibly, activating migration of the mobile genetic elements in the mutator line.

Authors:
; ;
Publication Date:
Research Org.:
M.V. Lomonosov Moscow State Univ. (USSR)
OSTI Identifier:
5826660
Resource Type:
Journal Article
Journal Name:
Sov. Genet. (Engl. Transl.); (United States)
Additional Journal Information:
Journal Volume: 24:5; Other Information: Translated from Genetika; 24: No. 5, 857-866(May 1988)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHROMOSOMAL ABERRATIONS; STRUCTURAL CHEMICAL ANALYSIS; DROSOPHILA; MUTANTS; GENE MUTATIONS; NERVE CELLS; SPONTANEOUS MUTATIONS; CHROMATIDS; CHROMOSOME BREAKAGE; CYTOLOGY; GANGLIONS; GENETIC EFFECTS; GENETICS; INSTABILITY; LARVAE; MITOSIS; MORPHOLOGICAL CHANGES; MUTATION FREQUENCY; REVERTANTS; SISTER CHROMATID EXCHANGES; ANIMAL CELLS; ANIMALS; ARTHROPODS; BIOLOGICAL EFFECTS; BIOLOGY; CELL DIVISION; DIPTERA; FLIES; FRUIT FLIES; INSECTS; INVERTEBRATES; MUTATIONS; NERVOUS SYSTEM; SOMATIC CELLS; 550400* - Genetics; 550300 - Cytology

Citation Formats

Derzhavets, E M, Kim, A I, and Aslanyan, M M. Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster. United States: N. p., 1988. Web.
Derzhavets, E M, Kim, A I, & Aslanyan, M M. Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster. United States.
Derzhavets, E M, Kim, A I, and Aslanyan, M M. 1988. "Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster". United States.
@article{osti_5826660,
title = {Analysis of spontaneous chromosomal rearrangements in neuroblasts of genetically unstable mutant lines of Drosophila melanogaster},
author = {Derzhavets, E M and Kim, A I and Aslanyan, M M},
abstractNote = {The spectrum and frequency of chromosomal aberrations in the somatic cells of III instar larvae of Drosophila melanogaster mutator line were studied using three of its derivatives (sbt, if, and w/sup a/) and line w as control. It has been demonstrated that the frequency of anaphases with bridges and acentric fragments increases in the neuroblast of flies of the mutator line as well as in the neuroblasts of the larvae of the lines sbt, if, and w/sup a/. The metaphase analysis revealed that the mutator line and its derivatives are characterized by higher frequencies of chromosomal aberrations as compared to the control. Chromatid breaks are predominant type of rearrangements. These results, suggest probably presence of the specific mutator factor or factors in the line studied, affecting chromosomal structure and, possibly, activating migration of the mobile genetic elements in the mutator line.},
doi = {},
url = {https://www.osti.gov/biblio/5826660}, journal = {Sov. Genet. (Engl. Transl.); (United States)},
number = ,
volume = 24:5,
place = {United States},
year = {Tue Nov 01 00:00:00 EST 1988},
month = {Tue Nov 01 00:00:00 EST 1988}
}