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Title: Genetic variants of serum albumin in Americans and Japanese

A collaborative search for albumin genetic variants (alloalbumins) was undertaken by cellulose acetate and agarose electrophoresis at pH 8.6 of the sera of patients at two major medical centers in the United States and of nearly 20,000 blood donors in Japan. Seventeen instances of alloalbuminemia were ascertained, and seven different alloalbumin types were characterized by structural study. Two previously unreported alloalbumin types were identified. All of the variants characterized in this study are point mutants, and the sites are spread throughout the albumin gene. However, about one-fourth of all known albumin mutations are clustered in the sequence segment from position 354 through 382.
Authors:
; ; ; ;  [1] ;  [2] ;  [3] ;  [4] ; ;  [5]
  1. (Indiana Univ., Bloomington (United States))
  2. (Josai Univ., Saitama (Japan))
  3. (Univ. of Iowa, Iowa City (United States))
  4. (Mayo Clinic, Rochester, MN (United States))
  5. (Japanese Red Cross, Tokyo (Japan))
Publication Date:
OSTI Identifier:
5826515
Resource Type:
Journal Article
Resource Relation:
Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States); Journal Volume: 88:21
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ALBUMINS; AMINO ACID SEQUENCE; ARGININE; ASPARTIC ACID; BIOLOGICAL EVOLUTION; BLOOD SERUM; ELECTROPHORESIS; GENE MUTATIONS; HISTIDINE; HUMAN POPULATIONS; JAPAN; SCREENING; USA; AMINO ACIDS; ASIA; AZOLES; CARBOXYLIC ACIDS; DEVELOPED COUNTRIES; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; MOLECULAR STRUCTURE; MUTATIONS; NORTH AMERICA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POPULATIONS; PROTEINS 550200* -- Biochemistry