Genetic variants of serum albumin in Americans and Japanese

Journal Article · Fri Nov 01 00:00:00 EST 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.21.9853· OSTI ID:5826515

Madison, J; Sakamoto, Yasushi; Watkins, S; Davis, E; Putnam, F W ^[1]; Arai, Kunio ^[2]; Feld, R D ^[3]; Kyle, R A ^[4]; Matsuda, Yuhichi; Amaki, Itta ^[5]

---

1. Indiana Univ., Bloomington (United States)
2. Josai Univ., Saitama (Japan)
3. Univ. of Iowa, Iowa City (United States)
4. Mayo Clinic, Rochester, MN (United States)
5. Japanese Red Cross, Tokyo (Japan)

A collaborative search for albumin genetic variants (alloalbumins) was undertaken by cellulose acetate and agarose electrophoresis at pH 8.6 of the sera of patients at two major medical centers in the United States and of nearly 20,000 blood donors in Japan. Seventeen instances of alloalbuminemia were ascertained, and seven different alloalbumin types were characterized by structural study. Two previously unreported alloalbumin types were identified. All of the variants characterized in this study are point mutants, and the sites are spread throughout the albumin gene. However, about one-fourth of all known albumin mutations are clustered in the sequence segment from position 354 through 382.

• OSTI ID: 5826515
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 88:21; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMINO ACID SEQUENCE
ARGININE
ASPARTIC ACID
BIOLOGICAL EVOLUTION
BLOOD SERUM
ELECTROPHORESIS
GENE MUTATIONS
HISTIDINE
HUMAN POPULATIONS
JAPAN
SCREENING
USA
AMINO ACIDS
ASIA
AZOLES
CARBOXYLIC ACIDS
DEVELOPED COUNTRIES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
MOLECULAR STRUCTURE
MUTATIONS
NORTH AMERICA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POPULATIONS
PROTEINS
550200* - Biochemistry