An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene

Hyman, S E; Comb, M; Pearlberg, J; Goodman, H M

doi:10.1128/MCB.9.1.321

Title: An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene

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Abstract

An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP-and phorbol ester-inducible transcription of the human proenkephalin gene. The authors report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.

Authors:: Hyman, S E; Comb, M; Pearlberg, J; Goodman, H M

Publication Date:: Sun Jan 01 00:00:00 EST 1989

Research Org.:: Molecular Neuropeptides Lab., Neuroscience Center, Massachusetts General Hospital East, Charlestown, MA (US); Massachusetts General Hospital, Boston, MA (USA). Dept. of Molecular Biology

OSTI Identifier:: 5822289

Resource Type:: Journal Article

Journal Name:: Mol. Cell. Biol.; (United States)

Additional Journal Information:: Journal Volume: 9:1

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; ENKEPHALINS; GENES; GENETIC MAPPING; TRANSCRIPTION; BIOLOGICAL PATHWAYS; AMP; DNA SEQUENCING; GENE REPRESSORS; PHORBOL ESTERS; AUTONOMIC NERVOUS SYSTEM AGENTS; CARCINOGENS; DRUGS; ENDORPHINS; ESTERS; MAPPING; NEUROREGULATORS; NUCLEOPROTEINS; NUCLEOTIDES; ORGANIC COMPOUNDS; PEPTIDES; POLYPEPTIDES; PROTEINS; STRUCTURAL CHEMICAL ANALYSIS; 550400* - Genetics; 550200 - Biochemistry

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                    Hyman, S E, Comb, M, Pearlberg, J, and Goodman, H M. An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene.  United States: N. p., 1989. 
        Web.  doi:10.1128/MCB.9.1.321.

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                    Hyman, S E, Comb, M, Pearlberg, J, & Goodman, H M. An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene.  United States.  https://doi.org/10.1128/MCB.9.1.321

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                    Hyman, S E, Comb, M, Pearlberg, J, and Goodman, H M. 1989.  
        "An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene".  United States.  https://doi.org/10.1128/MCB.9.1.321.

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@article{osti_5822289,

  title        = {An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene},

  author       = {Hyman, S E and Comb, M and Pearlberg, J and Goodman, H M},

  abstractNote = {An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP-and phorbol ester-inducible transcription of the human proenkephalin gene. The authors report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.},

  doi          = {10.1128/MCB.9.1.321},

  url          = {https://www.osti.gov/biblio/5822289},
  journal      = {Mol. Cell. Biol.; (United States)},
number       = ,

  volume       = 9:1,

  place        = {United States},

  year         = {Sun Jan 01 00:00:00 EST 1989},

  month        = {Sun Jan 01 00:00:00 EST 1989}

}

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