Renal uptake of technetium-99m methylene diphosphonate following therapeutic radiation for vertebral metastases

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · J. Nucl. Med.; (United States)

OSTI ID:5820731

Titelbaum, D S; Fowble, B F; Powe, J E; Martinez, F J

Radionuclide bone scans in two patients with breast cancer and concurrent chemotherapy treatment revealed increased band-like uptake of (/sup 99m/Tc)methylene diphosphonate along the medial upper renal cortex corresponding to the portions of the kidneys included within the radiation field. The latency of onset of abnormal uptake was 5 to 9 mo following completion of radiation in one patient, peaked near 13 to 14 mo for both patients, and returned to baseline after 20 to 27 mo. Transient serum creatinine level elevations were also detected. These findings suggest that transient subclinical renal impairment may occur and be detected on bone scans following inadvertent inclusion of renal cortex in radiation fields.

• Research Organization: Hospital of the Univ. of Pennsylvania, Philadelphia (USA)
• OSTI ID: 5820731
• Journal Information: J. Nucl. Med.; (United States), Vol. 30:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
SKELETON
RADIOISOTOPE SCANNING
TECHNETIUM 99
UPTAKE
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
CREATININE
ISOMERIC NUCLEI
KIDNEYS
MAMMARY GLANDS
PATIENTS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DISEASES
GLANDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics