Measurement of total-body oxygen, nitrogen, and carbon in vivo by photon activation analysis
With the aim of assessing nutritional status, the feasibility of measuring the total body quantities of the major body elements, i.e. oxygen, nitrogen, and carbon, using the photon beam of a 45 MV betatron and a whole-body counter, has been evaluated in detail. Following photon activation a single energy ..gamma..-radiation (.511 MeV) is observed from all three elements to be measured. The half-lives of /sup 15/O, /sup 13/N, and /sup 11/C, however, are sufficiently different (20.5 min, 10.0 min, and 20.4 min. respectively) to permit their measurement from an analysis of the measured decay curve. Following corrections for interfering reactions, a computer curve-fitting algorithm is used to resolve the data into /sup 15/O, /sup 13/N, and /sup 11/C components. Measurements of O, N, and C have been made both in phantoms and in live and dead rats. A comparison of the body composition results from this technique with results from chemical analysis indicates that measured carbon can quite accurately predict total body fat. The comparison of the total body nitrogen measurement by photon activation with total body protein by chemical analysis was inconclusive and suggests that further work be done to verify the estimated accuracy of the nitrogen measurement.
- Research Organization:
- Tufts Univ., Medford, MA (USA)
- OSTI ID:
- 5813318
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
CARBON
ACTIVATION ANALYSIS
BODY COMPOSITION
NITROGEN
OXYGEN
ALGORITHMS
CARBON 11
CHEMICAL COMPOSITION
IN VIVO
MAN
NITROGEN 13
OXYGEN 15
PHANTOMS
PHOTONS
RADIATION DOSES
RATS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON ISOTOPES
CHEMICAL ANALYSIS
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTARY PARTICLES
ELEMENTS
EVEN-ODD NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MASSLESS PARTICLES
MATHEMATICAL LOGIC
MINUTES LIVING RADIOISOTOPES
MOCKUP
NITROGEN ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
RODENTS
STRUCTURAL MODELS
VERTEBRATES
400101* - Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
550200 - Biochemistry