Copper-cadmium interaction in mice: effects of copper status on retention and distribution of cadmium after cadmium exposure
The role of increased dietary copper in altering the accumulation of cadmium and other metals in tissues, was investigated. Female Swiss-Webster mice were pretreated with cadmium or copper in drinking water for three weeks prior to cadmium exposure for an additional nine weeks, with sub groups from each dose level receiving Cu additions to the Cd supplemented water. In Cd pretreated animals, a significant decrease was observed in Cd concentrations in liver and kidney when Cu was added to Cd in drinking water. Cadmium levels in soluble protein fractions of liver of animals administered 5 ppm Cd were approximately three fold greater than that for the same Cd dose when Cu was added. The same was the case for the metallothionein-like protein fraction (MTP) of the liver cytosol. In copper pretreated animals similar trends were noted in that brain, spleen, liver (but not kidney) Cd levels were decreased in animals receiving Cu additions to the Cd dose. Increased binding of Cd to the MTP fraction was observed after both in vivo and in vitro exposure of intestinal mucosal cells to cadmium.
- Research Organization:
- Utah State Univ., Logan (USA)
- OSTI ID:
- 5807333
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CADMIUM 109
RETENTION
TISSUE DISTRIBUTION
CADMIUM COMPOUNDS
COPPER COMPOUNDS
BIOLOGICAL EFFECTS
BRAIN
DRINKING WATER
KIDNEYS
LIVER
METALLOTHIONEIN
MICE
SPLEEN
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METALLOPROTEINS
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques