Determining effect of pollutants on the immune system. Final report
The purpose of this project was to determine the effects of fly-ash inhalation on the ability of animals to resist infections, neoplastic growth, and the development of hypersensitive responses. Mice were exposed to fly ash from two different sources, carbon black, and filtered ambient air only. Following exposures of various lengths (days to months), a variety of tests were done to determine the immunologic competence of lymphocytes, neutrophiles, and macrophages. Fly ash had a suppressive effect on the ability of mice to respond to Escherichia coli antigens given by aerosol; this suppression was much less severe than that following exposures to carbon black. Fly ash had little effect on the ability of B and T lymphocytes to respond to mitogens and to be stimulated for cytolytic response against tumor cells. The cellular response of BCG-sensitized mice to purified protein derivative of tuberculin was enhanced. The effect of fly ash on macrophages was more pronounced, involving decreased phagocytic activity, decreased antibody-dependent cytolosis, increased cytoxic activity against tumor cells, and decreased ability to activate T cell mitogenesis.
- Research Organization:
- Pennsylvania State Univ., University Park (USA)
- OSTI ID:
- 5805718
- Report Number(s):
- PB-81-171829
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
FLY ASH
BIOLOGICAL EFFECTS
AEROSOLS
ANTIGENS
ESCHERICHIA COLI
INFECTIVITY
INHALATION
LABORATORY ANIMALS
LYMPHOCYTES
MICE
NEOPLASMS
RETICULOENDOTHELIAL SYSTEM
AEROSOL WASTES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ASHES
BACTERIA
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COLLOIDS
CONNECTIVE TISSUE CELLS
DISEASES
DISPERSIONS
INTAKE
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
RESIDUES
RODENTS
SOLS
SOMATIC CELLS
TISSUES
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)