Quantitative autoradiography of angiotensin II receptors in brain and kidney: focus on cardiovascular implications

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Prog. Clin. Biol. Res.; (United States)

OSTI ID:5804292

Gehlert, D R; Speth, R C; Wamsley, J K

Quantitative techniques of receptor autoradiography have been applied to localize (/sup 125/I)-angiotensin II binding sites in brain and kidney. High densities of autoradiographic grains, indicating the presence of angiotensin II receptors, have been localized to several rat brain nuclei including the dorsal motor nucleus of the vagus, nucleus of the solitary tract, anterior pituitary, locus coeruleus and several hypothalamic nuclei. Cat thoracic spinal cord exhibited a high density of sites over the intermedio-lateral cell column. In sections of rat kidney, angiotensin II receptors were detected in the glomerulus, vasa recta and ureter. The cardiovascular implications of these results are apparent and relate angiotensin II to hypertensive mechanisms. Thus, angiotensin II represents an endocoid which is involved in control of blood pressure through its effects on peripheral organs as well as the central nervous system.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City
• OSTI ID: 5804292
• Journal Information: Prog. Clin. Biol. Res.; (United States), Journal Name: Prog. Clin. Biol. Res.; (United States)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
RECEPTORS
AUTORADIOGRAPHY
BRAIN
CARDIOVASCULAR SYSTEM
CATS
IODINE 125
KIDNEYS
LABELLED COMPOUNDS
RATS
SPINAL CORD
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RODENTS
VASOCONSTRICTORS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques