Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells
Journal Article
·
· Antimicrobial Agents and Chemotherapy; (USA)
- National Cancer Institute, Bethesda, MD (USA)
The effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (AZT) were studied in various human mononuclear cell preparations. Thymidine suppressed ({sup 3}H)AZT phosphorylation in the same concentration range (20 to 100 microM) in which it antagonizes the anti-human immunodeficiency virus activity of AZT. Uridine, in turn, had no influence on AZT phosphorylation, just as it has no effect on the anti-human immunodeficiency virus activity of AZT. These findings are consistent with a close relationship between the inhibition of AZT phosphorylation and the influence of physiological nucleosides on the antiviral activity of AZT.
- OSTI ID:
- 5803054
- Journal Information:
- Antimicrobial Agents and Chemotherapy; (USA), Vol. 35:1; ISSN 0066-4804
- Country of Publication:
- United States
- Language:
- English
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·
OSTI ID:5803054
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Structure of the anti-human immunodeficiency virus agent 3 prime -fluoro-3 prime -deoxythymidine and electronic charge calculations for 3 prime -deoxythymidines
Journal Article
·
Tue May 01 00:00:00 EDT 1990
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5803054
Biotransformation in various species and in humans of 3'-azido-3'-deoxythymidine, a potential agent for the treatment of AIDS
Conference
·
Sat Mar 01 00:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5803054
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DRUGS
PHOSPHORYLATION
THYMIDINE
BIOCHEMICAL REACTION KINETICS
URIDINE
AIDS
BONE MARROW
DOSE-RESPONSE RELATIONSHIPS
MACROPHAGES
MAN
MONOCYTES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DISEASES
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
KINETICS
LEUKOCYTES
MAMMALS
MATERIALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHAGOCYTES
PRIMATES
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
SOMATIC CELLS
TISSUES
URACILS
VERTEBRATES
VIRAL DISEASES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques
DRUGS
PHOSPHORYLATION
THYMIDINE
BIOCHEMICAL REACTION KINETICS
URIDINE
AIDS
BONE MARROW
DOSE-RESPONSE RELATIONSHIPS
MACROPHAGES
MAN
MONOCYTES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DISEASES
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
KINETICS
LEUKOCYTES
MAMMALS
MATERIALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHAGOCYTES
PRIMATES
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
SOMATIC CELLS
TISSUES
URACILS
VERTEBRATES
VIRAL DISEASES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques