Postoperative irradiation of fresh autogenic cancellous bone grafts
Discontinuity defects were created in the mandibles of dogs and then reconstructed immediately with fresh autogenic cancellous bone grafts and Dacron-urethane prostheses. The grafts were irradiated to a total dose of 5000 rads after waiting intervals of between 3 and 12 weeks. Nonirradiated grafts served as controls. The grafts were evaluated clinically, radiographically, and histologically. There was complete incorporation of all grafts, regardless of the interval between surgery and radiotherapy. There were no soft-tissue complications. The controls were distinguishable from the irradiated grafts only by the presence of hematopoietic bone marrow. Fibrofatty marrow was observed in the irradiated grafts. Theoretical support for this technique is found in the biology of cancellous bone grafting and the pathology of radiation injury. In view of the difficulties associated with mandibular bone grafting in preoperatively irradiated patients, a new method of reconstructing selected cancer patients who require both mandibular resection and radiotherapy is suggested.
- OSTI ID:
- 5802689
- Journal Information:
- Plast. Reconstr. Surg.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GRAFTS
IRRADIATION
JAW
BONE TISSUES
DOGS
RADIATION DOSES
SURVIVAL TIME
URETHANE
ANIMAL TISSUES
ANIMALS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CONNECTIVE TISSUE
DOSES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
SKELETON
SKULL
TISSUES
TRANSPLANTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals