Pathology of diethylnitrosamine toxicity in the fish Rivulus marmoratus

Journal Article · Fri Nov 01 00:00:00 EST 1985 · J. Environ. Pathol., Toxicol. Oncol.; (United States)

OSTI ID:5801943

Thiyagarajah, A; Grizzle, J M

Rivulus marmoratus were exposed to 0, 10, 21, 45, 95, or 200 mg/liter diethylnitrosamine (DEN) for 6 weeks and examined 12 weeks after the end of exposure. Fatty change, hepatocellular glycogenosis, multiple basophilic foci, enlarged and distorted cells with or without an enlarged nucleus, and hyaline bodies and cytological alterations observed after exposure to DEN. Hemangiomas, cholangiomas, biliary cystadenomas, and glandular, trabecular and anaplastic hepatocellular carcinomas were observed at the 18th week. Only those fish exposed to 95 mg/liter DEN had cavernous hemangiomas and peliosis-like lesions, which could be a preneoplastic lesion preceding cavernous hemangiomas. Adenomatous hyperplasia of thyroid and granulomas were other chronic reactions caused by DEN toxicosis.

• Research Organization: Auburn Univ., AL
• OSTI ID: 5801943
• Journal Information: J. Environ. Pathol., Toxicol. Oncol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIVER
PATHOLOGICAL CHANGES
NITROSAMINES
TOXICITY
FISHES
LIVER CELLS
NECROSIS
NEOPLASMS
AMINES
ANIMAL CELLS
ANIMALS
AQUATIC ORGANISMS
BODY
DIGESTIVE SYSTEM
DISEASES
GLANDS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)