Elimination of soluble sup 123 I-labeled aggregates of IgG in patients with systemic lupus erythematosus. Effect of serum IgG and numbers of erythrocyte complement receptor type 1

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Arthritis and Rheumatism; (USA)

DOI:https://doi.org/10.1002/art.1780340409· OSTI ID:5800942

Halma, C; Breedveld, F C; Daha, M R; Blok, D; Evers-Schouten, J H; Hermans, J; Pauwels, E K; van Es, L A ^[1]

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1. Univ. Hospital Leiden (Netherlands)

Using soluble {sup 123}I-labeled aggregates of human IgG ({sup 123}I-AHIgG) as a probe, we examined the function of the mononuclear phagocyte system in 22 patients with systemic lupus erythematosus (SLE) and 12 healthy controls. In SLE patients, a decreased number of erythrocyte complement receptor type 1 was associated with less binding of {sup 123}I-AHIgG to erythrocytes and a faster initial rate of elimination of {sup 123}I-AHIgG (mean +/- SEM half-maximal clearance time 5.23 +/- 0.2 minutes, versus 6.58 +/- 0.2 minutes in the controls), with possible spillover of the material outside the mononuclear phagocyte system of the liver and spleen. However, multiple regression analysis showed that serum concentrations of IgG were the most important factor predicting the rate of {sup 123}I-AHIgG elimination. IgG concentration may thus reflect immune complex clearance, which in turn, would influence the inflammatory reaction, in SLE.

• OSTI ID: 5800942
• Journal Information: Arthritis and Rheumatism; (USA), Vol. 34:4; ISSN 0004-3591
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COMPLEMENT
RECEPTORS
IMMUNOGLOBULINS
BIOCHEMICAL REACTION KINETICS
LUPUS
PATHOGENESIS
ERYTHROCYTES
IODINE 123
LIVER
MACROPHAGES
METABOLISM
MONOCYTES
REGRESSION ANALYSIS
SOLUBILITY
SPLEEN
TRACER TECHNIQUES
ANIMAL CELLS
BACTERIAL DISEASES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
GLOBULINS
HOURS LIVING RADIOISOTOPES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LEUKOCYTES
MATERIALS
MATHEMATICS
MEMBRANE PROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RADIOISOTOPES
REACTION KINETICS
SOMATIC CELLS
STATISTICS
TUBERCULOSIS
550901* - Pathology- Tracer Techniques