Comparison of lung burdens of inhaled particles of rats exposed during the day or night

Hesseltine, G R; Wolff, R K; Hanson, R L; McClellan, R O; Mauderly, J L

doi:10.1080/15287398509530744

Title: Comparison of lung burdens of inhaled particles of rats exposed during the day or night

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Abstract

Inhalation studies frequently involve daytime exposures of nocturnal animals to toxicants. Such exposures may result in different respiratory tract depositions than would be obtained if rodents were exposed at night. Our study assessed the effect of night versus day exposures on lung burdens of particles inhaled by Fischer 344 rats. One group of 15 female rats was exposed to 0.3 micron volume median diameter particles of gallium oxide (Ga2O3) for 11.2 h during the day and a second group of 15 female rats was exposed to the same aerosol for 11.2 h at night. Gallium in the lungs at the end of exposure was measured by electrothermal atomic absorption spectrometry. Rats exposed during the night had significantly (p less than 0.05) higher lung burdens than day-exposed rats when burdens were expressed as either microgram Ga2O3/lung (mean +/- SD = 896 +/- 175 versus 698 +/- 150) or microgram Ga2O3/g lung (mean +/- SD = 683 +/- 134 versus 465 +/- 103). The greater amount of material in lungs of rats exposed at night probably reflected increased ventilation accompanying nocturnal activity.

Authors:: Hesseltine, G R; Wolff, R K; Hanson, R L; McClellan, R O; Mauderly, J L

Publication Date:: Tue Jan 01 00:00:00 EST 1985

Research Org.:: Inhalation Toxicology Research Institute, Albuquerque, NM

OSTI Identifier:: 5800054

Resource Type:: Journal Article

Journal Name:: J. Toxicol. Environ. Health; (United States)

Additional Journal Information:: Journal Volume: 2

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GALLIUM OXIDES; RETENTION; AEROSOLS; AIR POLLUTION; BODY BURDEN; DAILY VARIATIONS; DEPOSITS; INHALATION; LUNGS; PARTICULATES; RATS; RESPIRATION; RESPONSE MODIFYING FACTORS; ANIMALS; BODY; CHALCOGENIDES; COLLOIDS; DISPERSIONS; GALLIUM COMPOUNDS; INTAKE; MAMMALS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PARTICLES; POLLUTION; RESPIRATORY SYSTEM; RODENTS; SOLS; VARIATIONS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats


                    Hesseltine, G R, Wolff, R K, Hanson, R L, McClellan, R O, and Mauderly, J L. Comparison of lung burdens of inhaled particles of rats exposed during the day or night.  United States: N. p., 1985. 
        Web.  doi:10.1080/15287398509530744.

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                    Hesseltine, G R, Wolff, R K, Hanson, R L, McClellan, R O, & Mauderly, J L. Comparison of lung burdens of inhaled particles of rats exposed during the day or night.  United States.  https://doi.org/10.1080/15287398509530744

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                    Hesseltine, G R, Wolff, R K, Hanson, R L, McClellan, R O, and Mauderly, J L. 1985.  
        "Comparison of lung burdens of inhaled particles of rats exposed during the day or night".  United States.  https://doi.org/10.1080/15287398509530744.

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@article{osti_5800054,

  title        = {Comparison of lung burdens of inhaled particles of rats exposed during the day or night},

  author       = {Hesseltine, G R and Wolff, R K and Hanson, R L and McClellan, R O and Mauderly, J L},

  abstractNote = {Inhalation studies frequently involve daytime exposures of nocturnal animals to toxicants. Such exposures may result in different respiratory tract depositions than would be obtained if rodents were exposed at night. Our study assessed the effect of night versus day exposures on lung burdens of particles inhaled by Fischer 344 rats. One group of 15 female rats was exposed to 0.3 micron volume median diameter particles of gallium oxide (Ga2O3) for 11.2 h during the day and a second group of 15 female rats was exposed to the same aerosol for 11.2 h at night. Gallium in the lungs at the end of exposure was measured by electrothermal atomic absorption spectrometry. Rats exposed during the night had significantly (p less than 0.05) higher lung burdens than day-exposed rats when burdens were expressed as either microgram Ga2O3/lung (mean +/- SD = 896 +/- 175 versus 698 +/- 150) or microgram Ga2O3/g lung (mean +/- SD = 683 +/- 134 versus 465 +/- 103). The greater amount of material in lungs of rats exposed at night probably reflected increased ventilation accompanying nocturnal activity.},

  doi          = {10.1080/15287398509530744},

  url          = {https://www.osti.gov/biblio/5800054},
  journal      = {J. Toxicol. Environ. Health; (United States)},
number       = ,

  volume       = 2,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 1985},

  month        = {Tue Jan 01 00:00:00 EST 1985}

}

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