Cytostatic action of cells of the immune system on tumor cells
The authors study the ability of cells of the immune system to exert a cytostatic action on tumor cells. The target cells used were from mice, and all of the cells were insensitive to the cytotoxic action of the effector cells in the test with /sup 51/Cr. To prevent incorporation of /sup 3/H-uridine by the effector cells they were treated beforehand with actinomycin D. Nonadherent fractions of spleen, bone marrow and thymus cells were used in the experiments. Incorporation of /sup 3/H-thymidine and /sup 3/H-uridine into the cells was determined with a beta-counter. Analysis of the results of this investigation show that the ability of cells of different lymphoid organs to exhibit cytostatic activity is distinct from their ability to exert natural cytotoxic activity.
- Research Organization:
- Research Institute of Human Morphology, Moscow, USSR
- OSTI ID:
- 5785229
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 101:6; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 6, 744-746(Jun 1986)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW CELLS
BIOLOGICAL EFFECTS
SPLEEN CELLS
THYMUS CELLS
TUMOR CELLS
CELL KILLING
CYTOCHEMISTRY
TRACER TECHNIQUES
ANTIMITOTIC DRUGS
BIOSYNTHESIS
CARCINOGENESIS
CHROMIUM 51
DNA
IMMUNE REACTIONS
INHIBITION
LABELLED COMPOUNDS
LABELLING
MACROPHAGES
MICE
RNA
THYMIDINE
TRITIUM COMPOUNDS
URIDINE
ANIMAL CELLS
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
CHEMISTRY
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHAGOCYTES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
RODENTS
SOMATIC CELLS
SYNTHESIS
URACILS
VERTEBRATES
550301* - Cytology- Tracer Techniques
550901 - Pathology- Tracer Techniques