Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography (PET) of schizophrenic patients

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Am. J. Psychiatry; (United States)

OSTI ID:5777381

DeLisi, L E; Buchsbaum, M S; Holcomb, H H; Dowling-Zimmerman, S; Pickar, D; Boronow, J; Morihisa, J M; van Kammen, D P; Carpenter, W; Kessler, R

The finding in schizophrenic patients of a reversal of the normal frontal to posterior pattern of brain metabolic activity with positron emission tomography (PET) is of interest, but its relevance to psychopathology is unknown. Using PET, the authors studied 21 patients with chronic schizophrenia and 21 age- and sex-matched control subjects. Although eight of the 21 patients and only one of the control subjects showed a relatively lower anteroposterior metabolic gradient, no clinical correlates of this finding were noted. In addition, cerebral atrophy, as determined by CAT scan, was not associated with this aberrant metabolic pattern.

• Research Organization: National Inst. of Mental Health, Bethesda, MD
• OSTI ID: 5777381
• Journal Information: Am. J. Psychiatry; (United States), Vol. 142:1
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
BRAIN
ATROPHY
POSITRON COMPUTED TOMOGRAPHY
NERVOUS SYSTEM DISEASES
PATHOGENESIS
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METABOLISM
PATIENTS
BODY
CENTRAL NERVOUS SYSTEM
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DIAGNOSTIC TECHNIQUES
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