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Title: Renal handling of terephthalic acid

By use of the Sperber in vivo chicken preparation method, infusion of radiolabeled terephthalic acid ((/sup 14/C)TPA) into the renal portal circulation revealed a first-pass excretion of the unchanged compound into the urine. This model was utilized further to characterize the excretory transport of (/sup 14/C)TPA and provide information on the structural specificity in the secretion of dicarboxylic acids. At an infusion rate of 0.4 nmol/min. 60% of the (/sup 14/C)TPA which reached the kidney was directly excreted. An infusion rate of 3 or 6 mumol/min resulted in complete removal of (/sup 14/C)TPA by the kidney. These results indicate that TPA is both actively secreted and actively reabsorbed when infused at 0.4 nmol/min and that active reabsorption is saturated with the infusion of TPA at higher concentrations. The secretory process was saturated with the infusion of TPA at 40 mumol/mn. The excretory transport of TPA was inhibited by the infusion of probenecid, salicylate, and m-hydroxybenzoic acid, indicating that these organic acids share the same organic anion excretory transport process. m-Hydroxybenzoic acid did not alter the simultaneously measured excretory transport of p-aminohippuric acid (PAH), suggesting that there are different systems involved in the secretion of TPA and PAH. The structural specificitymore » for renal secretion of dicarboxylic acids was revealed by the use of o-phthalic acid and m-phthalic acid as possible inhibitors of TPA secretion.« less
Authors:
;
Publication Date:
OSTI Identifier:
5777304
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicol. Appl. Pharmacol.; (United States); Journal Volume: 77:1
Research Org:
Univ. of Minnesota, Minneapolis
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; TEREPHTHALIC ACID; RENAL CLEARANCE; BENZOIC ACID; BIOLOGICAL MODELS; CARBON 14 COMPOUNDS; CARBOXYLIC ACIDS; CHICKENS; EXCRETION; KIDNEYS; LIQUID COLUMN CHROMATOGRAPHY; RESPONSE MODIFYING FACTORS; TRACER TECHNIQUES; URIC ACID; URINE; ANIMALS; AROMATICS; AZAARENES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BIRDS; BODY; BODY FLUIDS; CHROMATOGRAPHY; CLEARANCE; DICARBOXYLIC ACIDS; FOWL; HETEROCYCLIC COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MATERIALS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PURINES; SEPARATION PROCESSES; VERTEBRATES; WASTES; XANTHINES 551001* -- Physiological Systems-- Tracer Techniques