Influence of occupational low-level lead exposure on renal parameters

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700120402· OSTI ID:5777215

Verschoor, M; Wibowo, A; Herber, R; van Hemmen, J; Zielhuis, R

The influence of lead exposure on renal function was examined. In 155 lead workers and 126 control workers, lead in blood (PbB) and zinc protoporphyrin in blood (ZPP) were measured as indicators of exposure to lead; various proteins in urine were measured as parameters of renal functions. Regression and matched-pair analyses suggest that tubular parameters may be more influenced by lead exposure than glomerular parameters. Changes in renal function parameters may already occur at PbB levels below 3 mumol/liter (600 micrograms/liter). The excretion of N-acetyl-beta-D-glucosaminidase appears to be the most consistent and sensitive parameter of an early effect on the tubular function.

• Research Organization: Univ. of Amsterdam, The Netherlands
• OSTI ID: 5777215
• Journal Information: Am. J. Ind. Med.; (United States), Vol. 12:4
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
DYNAMIC FUNCTION STUDIES
LEAD
METABOLISM
TOXICITY
BIOLOGICAL INDICATORS
BLOOD
GLYCOSYL HYDROLASES
OCCUPATIONAL EXPOSURE
PERSONNEL
REGRESSION ANALYSIS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
ELEMENTS
ENZYMES
HYDROLASES
MATERIALS
MATHEMATICS
METALS
ORGANS
STATISTICS
560300* - Chemicals Metabolism & Toxicology