Acrylamide: induction of heritable translocations in male mice
Acrylamide (AA), known to induce dominant lethals in male rodents, was studied in the mouse heritable translocation test by using intraperitoneal injections on 5 consecutive days. Matings on days 7-10 following the last injection yielded a high frequency of translocation carriers in the F/sub 1/ male population, which demonstrated that acrylamide is an effective inducer of translocations in postmeiotic germ cells. As an inducer of both dominant lethals and heritable translocations in late spermatids and early spermatozoa, AA is similar to alkylating agents such as ethylmethanesulfonate and ethylene oxide. However, AA's chemical structure, the nature of adducts formed with DNA, and its lack of mutagenicity in bacteria suggest a different mechanism as the basis for AA's germ cell mutagenicity.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5764593
- Journal Information:
- Environ. Mutagen.; (United States), Vol. 9:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACRYLAMIDE
GENETIC EFFECTS
CHROMOSOMAL ABERRATIONS
DNA ADDUCTS
DOMINANT MUTATIONS
INTRAPERITONEAL INJECTION
LETHAL MUTATIONS
MICE
MUTAGENESIS
ADDUCTS
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
INJECTION
INTAKE
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology