Histopathological changes in relation to cadmium concentration in horse kidneys

Journal Article · Thu Oct 01 00:00:00 EDT 1981 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(81)90179-1· OSTI ID:5760838

Elinder, C G; Jonsson, L; Piscator, M; Rahnster, B

Histopathological changes in kidney cortex, as observed by light microscopy, are related to cadmium concentration in kidney cortex from 69 normal Swedish horses. Cadmium concentrations in kidney ranged from 11 to 186 ..mu..g Cd/g wet wt with an average of 60 ..mu..g Cd/g, which is considerably higher than those normally found in humans. The microscopical changes were rated and related to cadmium concentrations in kidneys by dose-response curves. A relationship existed between frequency of morphological changes and cadmium concentration in the renal cortex. There was no obvious relationship between age and frequency of histopathological changes. This indicates that in horse kidneys morphological changes occur at cadmium concentrations which are lower than the tentative critical level for humans of 200 ..mu..g Cd/g. It is concluded that horses constitute a population at risk for environmental cadmium contamination.

• Research Organization: Swedish Univ. of Agricultural Sciences, Uppsala
• OSTI ID: 5760838
• Journal Information: Environ. Res.; (United States), Vol. 26:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
PATHOLOGICAL CHANGES
KIDNEYS
TOXICITY
HORSES
OPTICAL MICROSCOPY
QUANTITY RATIO
UPTAKE
ANIMALS
BODY
ELEMENTS
MAMMALS
METALS
MICROSCOPY
ORGANS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)