Manganese binding proteins in human and cow's milk

Journal Article · Fri Mar 01 00:00:00 EST 1985 · Am. J. Clin. Nutr.; (United States)

OSTI ID:5754894

Loennerdal, B; Keen, C L; Hurley, L S

Manganese nutrition in the neonatal period is poorly understood, due in part to a lack of information on the amount of manganese in infant foods and its bioavailability. Since the molecular localization of an element in foods is one determinant of its subsequent bioavailability, a study was made of the binding of manganese in human and cow's milk. An extrinsic label of /sup 54/Mn was shown to equilibrate isotopically with native manganese in milks and formulas. Milk samples were separated into fat, casein and whey by ultracentrifugation. In human milk, the major part (71%) of manganese was found in whey, 11% in casein and 18% in the lipid fraction. In contrast, in cow's milk, 32% of total manganese was in whey, 67% in casein and 1% in lipid. Within the human whey fraction, most of the manganese was bound to lactoferrin, while in cow's whey, manganese was mostly complexed to ligands with molecular weights less than 200. The distribution of manganese in formulas was closer to that of human milk than of cow's milk. The bioavailability of manganese associated with lactoferrin, casein and low molecular weight complexes needs to be assessed.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5754894
• Journal Information: Am. J. Clin. Nutr.; (United States), Vol. 41:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MANGANESE
BIOLOGICAL AVAILABILITY
PROTEINS
MOLECULAR STRUCTURE
CATTLE
CHEMICAL BONDS
COMPLEXES
DIET
INFANTS
ISOTOPE RATIO
LIGANDS
MAN
MANGANESE 54
MILK
MOLECULAR WEIGHT
TRACER TECHNIQUES
AGE GROUPS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
CHILDREN
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FOOD
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MANGANESE ISOTOPES
MATERIALS
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PRIMATES
RADIOISOTOPES
RUMINANTS
TRANSITION ELEMENTS
VERTEBRATES
550501* - Metabolism- Tracer Techniques