The effect of Hoe-427 (an ACTH sub 4-9 analog) on free-choice ethanol consumption in male and female rats
- Purdue Univ., West Lafayette, IN (United States)
Ethanol consummatory patterns of individual male and female rats and the effects of Hoe-427 (Ebiratide), and ACTH{sub 4-9} analog, thereon, were studied in a test system using 24 hour, two-bottle free choice consumption between 0.2% saccharin and 10% ethanol in 0.2% saccharin. Single, daily i.p. doses of either ACTH{sub 4-10} or its analog resulted in a significant reduction of daily ethanol consumption with no effects on saccharin consumption. After 4 days of treatment, male rats consistently exhibited a rebound increase in ethanol consumption; this effect was not seen in females. The daily ethanol consummatory patterns of the female animals seemed to exhibit a 4-6 day cyclic rhythymicity, suggesting an interaction with estrous cycles. These results support a role for ACTH{sub 4-10} in the initiation of ethanol consummatory behavior in rats and suggests the existence of sex differences in this phenomenon.
- OSTI ID:
- 5751544
- Journal Information:
- Life Sciences; (United States), Vol. 49:26; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADRENAL HORMONES
BIOCHEMICAL REACTION KINETICS
ETHANOL
BIOLOGICAL EFFECTS
ESTROUS CYCLE
RATS
SEX DEPENDENCE
ALCOHOLS
ANIMALS
HORMONES
HYDROXY COMPOUNDS
KINETICS
MAMMALS
ORGANIC COMPOUNDS
REACTION KINETICS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology