Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease

Journal Article · Sat Dec 01 00:00:00 EST 1984 · Am. J. Med. Sci.; (United States)

DOI:https://doi.org/10.1097/00000441-198412000-00005· OSTI ID:5749295

Jacobson, D R; Fleming, B J

The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy.

• Research Organization: Cleveland Veterans Administration Medical Center, OH
• OSTI ID: 5749295
• Journal Information: Am. J. Med. Sci.; (United States), Vol. 288:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
HODGKINS DISEASE
RADIOTHERAPY
HYPERTHYROIDISM
RADIOINDUCTION
SIDE EFFECTS
SENSE ORGANS DISEASES
ANTIGENS
DELAYED RADIATION EFFECTS
NECK
NEOPLASMS
PATIENTS
RADIATION INJURIES
RECOMMENDATIONS
SURVIVAL TIME
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DISEASES
ENDOCRINE DISEASES
INJURIES
LYMPHOMAS
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)