Modulation of radiation-induced hemopoietic suppression by acute thrombocytopenia
Modifications of radiation-induced hemopoietic suppression by acute thrombocytopenia were evaluated. Immediately before or after exposure to sublethal irradiation, mice were given a single injection of anti-mouse platelet serum (APS), normal heterologous serum, neuraminidase (N'ase), or saline, or no further treatment was provided. Hemopoiesis was evaluated by blood cell counts, hematocrits, and incorporation of (75Se)selenomethionine into platelets. APS and N'ase induced an acute thrombocytopenia from which there was partial recovery before the platelet count started to fall from the radiation. During the second post-treatment week, both thrombocytopoiesis and erythropoiesis were greater in mice that received APS or N'ase in addition to radiation than in control irradiated mice. Differences in leukopoiesis were not apparent. Therefore, both thrombocytopoiesis and erythropoiesis appeared to be responsive to a stimulus generated by acute thrombocytopenia in sublethally irradiated mice.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 5737707
- Journal Information:
- Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States)
- Country of Publication:
- United States
- Language:
- English
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STIMULATION
HEMATOPOIETIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
ANTIBODIES
BLOOD FORMATION
IMMUNE SERUMS
MICE
RADIOINDUCTION
SUBLETHAL IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
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560152* - Radiation Effects on Animals- Animals