Penetration of subarachnoid contrast medium into rabbit spinal cord. Comparison between metrizamide and iohexol
Abstract
The penetration into rabbit spinal cord of two nonionic contrast media, iohexol and metrizamide, and a reference tracer, technetium DTPA, were compared. The spinal subarachnoid space was perfused for 4 hours with a CSF solution to which technetium DTPA and either iohexol or metrizamide had been added. The contrast media and technetium DTPA concentrations reached a plateau level in CSF outflow within 80 minutes. The contrast media concentrations in CSF were higher than the technetium DTPA (P less than .001). In the cord tissue, technetium DTPA reached higher concentrations than the contrast media (P less than .001), and iohexol reached higher concentrations relative to technetium DTPA than metrizamide (P less than .001). The mean contrast media distribution volumes in the thoracic cord were 13% (iohexol) and 12% (metrizamide). The smaller distribution volume observed for metrizamide could be related to the larger effective size of associated metrizamide molecules or an interference with diffusion perhaps related to binding to glucose carriers.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Rochester Medical Center, NY
- OSTI Identifier:
- 5737338
- Resource Type:
- Journal Article
- Journal Name:
- Invest. Radiol.; (United States)
- Additional Journal Information:
- Journal Volume: 2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; IOHEXOL; TISSUE DISTRIBUTION; METRIZAMIDE; SPINAL CORD; RADIONUCLIDE KINETICS; TECHNETIUM 99; COMPARATIVE EVALUATIONS; CONTRAST MEDIA; DTPA; RABBITS; AMIDES; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHELATING AGENTS; DISTRIBUTION; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Holtas, S, Morris, T W, Ekholm, S E, Isaac, L, and Fonte, D. Penetration of subarachnoid contrast medium into rabbit spinal cord. Comparison between metrizamide and iohexol. United States: N. p., 1986.
Web. doi:10.1097/00004424-198602000-00012.
Holtas, S, Morris, T W, Ekholm, S E, Isaac, L, & Fonte, D. Penetration of subarachnoid contrast medium into rabbit spinal cord. Comparison between metrizamide and iohexol. United States. https://doi.org/10.1097/00004424-198602000-00012
Holtas, S, Morris, T W, Ekholm, S E, Isaac, L, and Fonte, D. 1986.
"Penetration of subarachnoid contrast medium into rabbit spinal cord. Comparison between metrizamide and iohexol". United States. https://doi.org/10.1097/00004424-198602000-00012.
@article{osti_5737338,
title = {Penetration of subarachnoid contrast medium into rabbit spinal cord. Comparison between metrizamide and iohexol},
author = {Holtas, S and Morris, T W and Ekholm, S E and Isaac, L and Fonte, D},
abstractNote = {The penetration into rabbit spinal cord of two nonionic contrast media, iohexol and metrizamide, and a reference tracer, technetium DTPA, were compared. The spinal subarachnoid space was perfused for 4 hours with a CSF solution to which technetium DTPA and either iohexol or metrizamide had been added. The contrast media and technetium DTPA concentrations reached a plateau level in CSF outflow within 80 minutes. The contrast media concentrations in CSF were higher than the technetium DTPA (P less than .001). In the cord tissue, technetium DTPA reached higher concentrations than the contrast media (P less than .001), and iohexol reached higher concentrations relative to technetium DTPA than metrizamide (P less than .001). The mean contrast media distribution volumes in the thoracic cord were 13% (iohexol) and 12% (metrizamide). The smaller distribution volume observed for metrizamide could be related to the larger effective size of associated metrizamide molecules or an interference with diffusion perhaps related to binding to glucose carriers.},
doi = {10.1097/00004424-198602000-00012},
url = {https://www.osti.gov/biblio/5737338},
journal = {Invest. Radiol.; (United States)},
number = ,
volume = 2,
place = {United States},
year = {Sat Feb 01 00:00:00 EST 1986},
month = {Sat Feb 01 00:00:00 EST 1986}
}