Penetration of subarachnoid contrast medium into rabbit spinal cord. Comparison between metrizamide and iohexol

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Invest. Radiol.; (United States)

DOI:https://doi.org/10.1097/00004424-198602000-00012· OSTI ID:5737338

Holtas, S; Morris, T W; Ekholm, S E; Isaac, L; Fonte, D

The penetration into rabbit spinal cord of two nonionic contrast media, iohexol and metrizamide, and a reference tracer, technetium DTPA, were compared. The spinal subarachnoid space was perfused for 4 hours with a CSF solution to which technetium DTPA and either iohexol or metrizamide had been added. The contrast media and technetium DTPA concentrations reached a plateau level in CSF outflow within 80 minutes. The contrast media concentrations in CSF were higher than the technetium DTPA (P less than .001). In the cord tissue, technetium DTPA reached higher concentrations than the contrast media (P less than .001), and iohexol reached higher concentrations relative to technetium DTPA than metrizamide (P less than .001). The mean contrast media distribution volumes in the thoracic cord were 13% (iohexol) and 12% (metrizamide). The smaller distribution volume observed for metrizamide could be related to the larger effective size of associated metrizamide molecules or an interference with diffusion perhaps related to binding to glucose carriers.

• Research Organization: Univ. of Rochester Medical Center, NY
• OSTI ID: 5737338
• Journal Information: Invest. Radiol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
IOHEXOL
TISSUE DISTRIBUTION
METRIZAMIDE
SPINAL CORD
RADIONUCLIDE KINETICS
TECHNETIUM 99
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
DTPA
RABBITS
AMIDES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
DISTRIBUTION
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
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