Myocardial distribution of indium-111-antimyosin Fab in acute inferior and right ventricular infarction: comparison with technetium-99m-pyrophosphate imaging and histologic examination

Journal Article · Wed May 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5734582

Nakata, T; Sakakibara, T; Noto, T; Shoji, T; Tsuda, T; Kubota, M; Hattori, A; Iimura, O ^[1]

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1. Sapporo Medical College, (Japan)

In a postmortem study of a 69-yr-old female patient who had suffered 2 yr previously a non-Q-wave anterior infarction and who had sustained just seven days earlier a left inferior and right ventricular infarction, the distribution of {sup 111}In-antimyosin Fab was compared to the results of {sup 99}mTc-pyrophosphate imaging and histologic examination. Indium-111-antimyosin Fab imaging could not be performed because of cardiogenic shock. However, postmortem gamma scintillation counting revealed increased activities of antimyosin Fab in the inferoapical and right ventricular infarcted regions in which {sup 99}mTc-pyrophosphate positive imagings were observed; in contrast, a histologically confirmed old subendocardial anterior infarction had no definite activity. Thus, the myocardial distribution of {sup 111}In-antimyosin Fab corresponded well to the results of {sup 99}mTc scintigrams and histologic examinations in a human heart, suggesting that this technique could be useful in vivo for detecting several-day-old myocardial infarction of the right ventricle as well as the left ventricle. Tissue from the 2-yr-old infarction was not identified by this technique.

• OSTI ID: 5734582
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:5; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
IMAGE PROCESSING
MYOCARDIAL INFARCTION
DIAGNOSIS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
COMPARATIVE EVALUATIONS
ISOMERIC NUCLEI
MONOCLONAL ANTIBODIES
ORGANOMETALLIC COMPOUNDS
PATIENTS
PYROPHOSPHATES
TECHNETIUM 99
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DISTRIBUTION
DRUGS
EVALUATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PROCESSING
RADIOISOTOPES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOI
550601* - Medicine- Unsealed Radionuclides in Diagnostics