Effects of moderate-intensity light on vitamin A-deficient rat retinas
Abstract
The effects of moderate-intensity light (150 to 200 ft-cd) on retinal structure were compared between retinol-adequate and retinol-deficient rats after 1 to 6 days of light exposure during the 12 hr light phase of the cycle. Both damage to the outer segments and loss of photoreceptor cells were accelerated in retinol-adequate rats. Outer segments in retinas of retinol-adequate rats showed an abnormal staining pattern and disruption of disc structure in the distal portion about 2 days before those of retinol-deficient rats. After 4 days of exposure 24% of the photoreceptor cells had degenerated in the retinol-adequate retinas, but only 6% in the retinol-deficient retinas. By 6 days 65% and 41% of the photoreceptors had degenerated in the retinol-adequate and retinol-deficient retinas, respectively. Thus light exposure induced more rapid degeneration of photoreceptor cells in rats receiving adequate retinol than in those deficient in this vitamin.
- Authors:
- Publication Date:
- OSTI Identifier:
- 5733670
- Resource Type:
- Journal Article
- Journal Name:
- Invest. Ophthalmol. Visual Sci.; (United States)
- Additional Journal Information:
- Journal Volume: 20:5
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RETINA; PHOTOSENSITIVITY; VITAMIN A; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CYTOLOGICAL TECHNIQUES; NUTRITIONAL DEFICIENCY; RATS; VISIBLE RADIATION; ANIMALS; BODY; BODY AREAS; ELECTROMAGNETIC RADIATION; EYES; FACE; HEAD; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SENSE ORGANS; SENSITIVITY; VERTEBRATES; VITAMINS; 560100* - Biomedical Sciences, Applied Studies- Radiation Effects
Citation Formats
Carter-Dawson, L, Kuwabara, T, and Bieri, J G. Effects of moderate-intensity light on vitamin A-deficient rat retinas. United States: N. p., 1981.
Web.
Carter-Dawson, L, Kuwabara, T, & Bieri, J G. Effects of moderate-intensity light on vitamin A-deficient rat retinas. United States.
Carter-Dawson, L, Kuwabara, T, and Bieri, J G. 1981.
"Effects of moderate-intensity light on vitamin A-deficient rat retinas". United States.
@article{osti_5733670,
title = {Effects of moderate-intensity light on vitamin A-deficient rat retinas},
author = {Carter-Dawson, L and Kuwabara, T and Bieri, J G},
abstractNote = {The effects of moderate-intensity light (150 to 200 ft-cd) on retinal structure were compared between retinol-adequate and retinol-deficient rats after 1 to 6 days of light exposure during the 12 hr light phase of the cycle. Both damage to the outer segments and loss of photoreceptor cells were accelerated in retinol-adequate rats. Outer segments in retinas of retinol-adequate rats showed an abnormal staining pattern and disruption of disc structure in the distal portion about 2 days before those of retinol-deficient rats. After 4 days of exposure 24% of the photoreceptor cells had degenerated in the retinol-adequate retinas, but only 6% in the retinol-deficient retinas. By 6 days 65% and 41% of the photoreceptors had degenerated in the retinol-adequate and retinol-deficient retinas, respectively. Thus light exposure induced more rapid degeneration of photoreceptor cells in rats receiving adequate retinol than in those deficient in this vitamin.},
doi = {},
url = {https://www.osti.gov/biblio/5733670},
journal = {Invest. Ophthalmol. Visual Sci.; (United States)},
number = ,
volume = 20:5,
place = {United States},
year = {Fri May 01 00:00:00 EDT 1981},
month = {Fri May 01 00:00:00 EDT 1981}
}