Examination of immune parameters and host-resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-'p'-dioxin
Adult female B6C3F1 mice were given a single IP dose of 0, 0.1, 1.0, or 10.0 micrograms/kg TCDD and examined for immune function and host resistance seven to ten days later. Exposure to TCDD resulted in a significant dose-related decrease in induction of both IgM and IgG antibody-forming cells. The suppression was noted for both T-dependent and T-independent antigens. TCDD at a dosage of 10 micrograms/kg was shown to suppress production of viral hemagglutinin. In contrast, TCDD exposure had no significant effect on natural killer cell function, production of interferon, or various parameters of macrophage function. Host resistance assessment revealed a significant increase in susceptibility to fatal infection with influenza virus, but no significant alteration in susceptibility to infection with the bacterium Listeria monocytogenes.
- Research Organization:
- Chemical Industry Inst. of Toxicology, Research Triangle Park, NC (USA)
- OSTI ID:
- 5733603
- Report Number(s):
- PB-91-163659/XAB; CNN: EPA-68-02-4450
- Resource Relation:
- Other Information: Pub. in Jnl. of Toxicology and Environmental Health, v31 n3 p203-215 Nov 90. Prepared in cooperation with IIT Research Inst., Chicago, IL. Life Sciences Research Div. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DIOXIN
TOXICITY
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
ANTIBODY FORMATION
DOSE-RESPONSE RELATIONSHIPS
INTERFERON
LYMPHOCYTES
MACROPHAGES
MICE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
GROWTH FACTORS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHAGOCYTES
PROTEINS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology