Gastrointestinal ulceration in the guinea pig in response to dimaprit, histamine, and H1- and H2-blocking agents

Journal Article · Wed Apr 01 00:00:00 EST 1981 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01308370· OSTI ID:5731693

Cho, C H; Pfeiffer, C J

Histamine is known to induce gastric ulcers in guinea pigs after intraperitoneal administration and duodenal ulcers after repeated intramuscular administrations. This study was undertaken to clarify further the differential role of H1 and H2 receptor sites in respect to gastric and duodenal ulcer in the guinea pig. Groups of guinea pigs were treated with histamine, intraperitoneal (1.81 mg/kg intraperitoneal) or intramuscular (0.09 mg/kg intramuscular X 8 doses); the selective H2 agonist dimaprit (0.09-0.18 mg/kg X 8 doses intramuscular or 1.81-3.62 mg/kg intraperitoneal); NaCl, 154 mM (control); and the selective H1 and H2 antagonists, diphenhydramine (125 mg/kg X 2 doses, intramuscular) or cimetidine (50 mg/kg X 3 doses, intramuscular). Gastric and duodenal lesions were evaluated and residual gastric contents were analyzed. The selective induction of gastric or duodenal ulceration by histamine was confirmed, and the H2 agonist, dimaprit, has been shown to be ulcerogenic to the guinea pig duodenum by intraperitoneal or intramuscular administration. Diphenhydramine produced considerably more protection against histamine-induced gastric ulceration (62% decrease in incidence), while cimetidine was particularly effective in the prevention of histamine-induced duodenal ulcer (64% decrease in incidence). A differential role of histamine in the pathogenesis of gastric as opposed to duodenal ulcer is suggested by the present findings.

• OSTI ID: 5731693
• Journal Information: Dig. Dis. Sci.; (United States), Vol. 26:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HISTAMINE
BIOLOGICAL EFFECTS
SMALL INTESTINE
SENSITIVITY
STOMACH
ULCERS
PATHOLOGY
BIOCHEMICAL REACTION KINETICS
GUINEA PIGS
INTRAMUSCULAR INJECTION
INTRAPERITONEAL INJECTION
RECEPTORS
AMINES
ANIMALS
AZOLES
BODY
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INJECTION
INTAKE
INTESTINES
KINETICS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
REACTION KINETICS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology
550200 - Biochemistry