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Title: Tissue pertechnetate and iodinated contrast material ischemic stroke

Abstract

Isotope uptake during static radionuclide scanning and contrast enhancement during CT scanning, which may result from similar pathophysiologic mechanisms after ischemic infarction, were investigated in an animal model. Infarction was produced by transorbital occlusion of the middle cerebral artery in cats killed one, 2, 4, 8, or 16 days later. Sodium pertechnetate containing technetium-99m and 30% methylglucamine iothalamate labeled with I-125 were administered intravenously 60 and 15 min respectively prior to sacrifice. A coronal section through the infarct was parceled into 30 portions which were assayed for concentration of each isotope. Adjacent brain was prepared for histopathologic correlation. Concentrations of the 2 materials were highest in infarcted brain at 4 and 8 days. Strong positive correlation was found between tissue concentrations of the 2 materials in all brain samples. Elevated tissue levels correlated with necrosis, macrophage infiltration, and vascular hyperplasia. The results support the probability that radionuclide scan positivity and CT contrast enhancement reflect the same pathophysiologic development, probably extravasation of the respective labels, after schemic stroke.

Authors:
; ; ;
Publication Date:
OSTI Identifier:
5728775
Resource Type:
Journal Article
Journal Name:
Stroke; (United States)
Additional Journal Information:
Journal Volume: 11:6
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BRAIN; SCINTISCANNING; IODINE 125; ISCHEMIA; DIAGNOSIS; TECHNETIUM 99; BIOLOGICAL MODELS; CATS; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; DIAGNOSTIC USES; ISOMERIC NUCLEI; PHYSIOLOGY; TISSUE DISTRIBUTION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; USES; VASCULAR DISEASES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Anderson, D C, Coss, D T, Jacobson, R L, and Meyer, M W. Tissue pertechnetate and iodinated contrast material ischemic stroke. United States: N. p., 1980. Web. doi:10.1161/01.STR.11.6.617.
Anderson, D C, Coss, D T, Jacobson, R L, & Meyer, M W. Tissue pertechnetate and iodinated contrast material ischemic stroke. United States. https://doi.org/10.1161/01.STR.11.6.617
Anderson, D C, Coss, D T, Jacobson, R L, and Meyer, M W. 1980. "Tissue pertechnetate and iodinated contrast material ischemic stroke". United States. https://doi.org/10.1161/01.STR.11.6.617.
@article{osti_5728775,
title = {Tissue pertechnetate and iodinated contrast material ischemic stroke},
author = {Anderson, D C and Coss, D T and Jacobson, R L and Meyer, M W},
abstractNote = {Isotope uptake during static radionuclide scanning and contrast enhancement during CT scanning, which may result from similar pathophysiologic mechanisms after ischemic infarction, were investigated in an animal model. Infarction was produced by transorbital occlusion of the middle cerebral artery in cats killed one, 2, 4, 8, or 16 days later. Sodium pertechnetate containing technetium-99m and 30% methylglucamine iothalamate labeled with I-125 were administered intravenously 60 and 15 min respectively prior to sacrifice. A coronal section through the infarct was parceled into 30 portions which were assayed for concentration of each isotope. Adjacent brain was prepared for histopathologic correlation. Concentrations of the 2 materials were highest in infarcted brain at 4 and 8 days. Strong positive correlation was found between tissue concentrations of the 2 materials in all brain samples. Elevated tissue levels correlated with necrosis, macrophage infiltration, and vascular hyperplasia. The results support the probability that radionuclide scan positivity and CT contrast enhancement reflect the same pathophysiologic development, probably extravasation of the respective labels, after schemic stroke.},
doi = {10.1161/01.STR.11.6.617},
url = {https://www.osti.gov/biblio/5728775}, journal = {Stroke; (United States)},
number = ,
volume = 11:6,
place = {United States},
year = {Sat Nov 01 00:00:00 EST 1980},
month = {Sat Nov 01 00:00:00 EST 1980}
}