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Title: Medulloblastoma in infants and children: computed tomographic follow-up after treatment

Thirty-six proven cases of medulloblastoma were reviewed by serial CT follow-up examinations from 4 months to 10 years, 2 months after the initial diagnosis, with a mean follow-up time of 3 years, 9 months. The tumor recurred at the primary site in 20 cases (56%). Leptomeningeal metastasis was demonstrated on CT in 14 cases (39%); seven of these patients also presented with solid subarachnoid metastases. Thirteen patients (36%) showed evidence of severe brain atrophy, which was confined to the posterior fossa in seven of the 13. Calcification resulting from mineralizing microangiopathy developed in five cases (14%), including three patients who had had extensive dystrophic calcification in the corticomedullary junction and the deep-seated nuclei of the cerebrum and cerebellum. The patterns of tumor recurrence in the posterior fossa that is severely deformed by surgery and other treatment modalities and leptomeningeal spread of tumor are discussed.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5728086
Report Number(s):
CONF-851152-
Journal ID: CODEN: RADLA; TRN: 85-015579
Resource Type:
Conference
Resource Relation:
Journal Name: Radiology; (United States); Journal Volume: 154:3; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
Research Org:
Univ. of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, Houston
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ATROPHY; RADIOINDUCTION; BRAIN; COMPUTERIZED TOMOGRAPHY; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; CALCINOSIS; CHILDREN; INFANTS; METASTASES; NEOPLASMS; AGE GROUPS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; THERAPY; TOMOGRAPHY 550602* -- Medicine-- External Radiation in Diagnostics-- (1980-); 550603 -- Medicine-- External Radiation in Therapy-- (1980-)