Medulloblastoma in infants and children: computed tomographic follow-up after treatment

Conference · Fri Mar 01 00:00:00 EST 1985 · Radiology; (United States)

OSTI ID:5728086

Lee, Y Y; Glass, J P; van Eys, J; Wallace, S

Thirty-six proven cases of medulloblastoma were reviewed by serial CT follow-up examinations from 4 months to 10 years, 2 months after the initial diagnosis, with a mean follow-up time of 3 years, 9 months. The tumor recurred at the primary site in 20 cases (56%). Leptomeningeal metastasis was demonstrated on CT in 14 cases (39%); seven of these patients also presented with solid subarachnoid metastases. Thirteen patients (36%) showed evidence of severe brain atrophy, which was confined to the posterior fossa in seven of the 13. Calcification resulting from mineralizing microangiopathy developed in five cases (14%), including three patients who had had extensive dystrophic calcification in the corticomedullary junction and the deep-seated nuclei of the cerebrum and cerebellum. The patterns of tumor recurrence in the posterior fossa that is severely deformed by surgery and other treatment modalities and leptomeningeal spread of tumor are discussed.

• Research Organization: Univ. of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, Houston
• OSTI ID: 5728086
• Report Number(s): CONF-851152-; TRN: 85-015579
• Journal Information: Radiology; (United States), Vol. 154:3; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ATROPHY
RADIOINDUCTION
BRAIN
COMPUTERIZED TOMOGRAPHY
DELAYED RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
CALCINOSIS
CHILDREN
INFANTS
METASTASES
NEOPLASMS
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
THERAPY
TOMOGRAPHY
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550603 - Medicine- External Radiation in Therapy- (1980-)