Combined laboratory and epidemiological study of the effect of load on the excretion of Beta aminoisobutyric acid
Beta Aminoisobutyric Acid (BAIB) is the end product of the catabolism of thymine. BAIB is actively secreted and is a common component of human urine. Since lead has not been reported to degrade DNA we were surprised to find elevated amounts of BAIB in the urine of workers who had lead poisoning. To further study this phenomenon a group of 26 males engaged in demolition work which exposed them to lead was compared to a control group of 40 male hospital workers with regard to BAIB excretion. The exposed workers excreted an average of 19.26 nmoles of BAIB per ..mu..mole creatinine. The value for the control group was 6.02. In order to determine the effect of lead on BAIB excretion under controlled conditions, the authors exposed marmosets to different doses of lead and monitored the lead poisoning via the blood level of zinc protoporphyrin. They found a strong correlation between exposure to lead and excretion of BAIB.
- Research Organization:
- Univ. of Tennessee, Knoxville
- OSTI ID:
- 5718686
- Report Number(s):
- CONF-8611204-
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 184:4; Conference: Annual meeting of the Southeast Section of the Society for Experimental Biology and Medicine, Chapel Hill, NC, USA, 13 Nov 1986
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of environmental lead levels on the urinary kallikrein excretion of exposed workers
Surveillance of workers exposed to mercury vapor:validation of a previously proposed biological threshold limit value for mercury concentration in urine
Related Subjects
AMINOBUTYRIC ACID
EXCRETION
LEAD
TOXICITY
BIOLOGICAL MODELS
EPIDEMIOLOGY
MONKEYS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
URINE
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
DRUGS
ELEMENTS
MAMMALS
MATERIALS
METALS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology