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Title: Olfactory neuroblastoma

Abstract

Fifteen patients with olfactory neuroblastoma were treated during the 17-year period of 1969 to 1986. Data was analyzed with respect to age at presentation, sex, presenting signs and symptoms, stage, and results of treatment. Age ranged from 4 to 67 years with the median age being 27 years. Median follow-up was 8 years. Local control was achieved in nine of nine patients or 100% with successful surgical resection, i.e., minimal residual disease, followed by postoperative radiation therapy (45 to 65 Gy) was employed. There were no distant failures when the primary site was controlled. Regional lymph node metastases were infrequent: only 13% (two of 15 patients) presented with positive nodes. Three of four patients treated initially with surgery alone had a local recurrence, two of which were successfully salvaged by combined therapy. There were four patients treated with radiation therapy alone: three had persistent disease after radiation therapy, and one patient was controlled with 65 Gy. Olfactory neuroblastoma has a propensity to recur locally when treated with surgery alone. The authors' experience suggests excellent local control can be achieved with surgery immediately followed by radiation therapy. Thus the authors recommend planned combined treatment for all resectable lesions.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of California Los Angeles (USA)
OSTI Identifier:
5717504
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 63:12
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; RADIOTHERAPY; SURGERY; OLFACTORY BULBS; LYMPH NODES; METASTASES; PATIENTS; RADIATION INJURIES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; DISEASES; INJURIES; LYMPHATIC SYSTEM; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 550600 - Medicine

Citation Formats

O'Connor, T A, McLean, P, Juillard, G J, and Parker, R G. Olfactory neuroblastoma. United States: N. p., 1989. Web. doi:10.1002/1097-0142(19890615)63:12<2426::AID-CNCR2820631209>3.0.CO;2-K.
O'Connor, T A, McLean, P, Juillard, G J, & Parker, R G. Olfactory neuroblastoma. United States. https://doi.org/10.1002/1097-0142(19890615)63:12<2426::AID-CNCR2820631209>3.0.CO;2-K
O'Connor, T A, McLean, P, Juillard, G J, and Parker, R G. 1989. "Olfactory neuroblastoma". United States. https://doi.org/10.1002/1097-0142(19890615)63:12<2426::AID-CNCR2820631209>3.0.CO;2-K.
@article{osti_5717504,
title = {Olfactory neuroblastoma},
author = {O'Connor, T A and McLean, P and Juillard, G J and Parker, R G},
abstractNote = {Fifteen patients with olfactory neuroblastoma were treated during the 17-year period of 1969 to 1986. Data was analyzed with respect to age at presentation, sex, presenting signs and symptoms, stage, and results of treatment. Age ranged from 4 to 67 years with the median age being 27 years. Median follow-up was 8 years. Local control was achieved in nine of nine patients or 100% with successful surgical resection, i.e., minimal residual disease, followed by postoperative radiation therapy (45 to 65 Gy) was employed. There were no distant failures when the primary site was controlled. Regional lymph node metastases were infrequent: only 13% (two of 15 patients) presented with positive nodes. Three of four patients treated initially with surgery alone had a local recurrence, two of which were successfully salvaged by combined therapy. There were four patients treated with radiation therapy alone: three had persistent disease after radiation therapy, and one patient was controlled with 65 Gy. Olfactory neuroblastoma has a propensity to recur locally when treated with surgery alone. The authors' experience suggests excellent local control can be achieved with surgery immediately followed by radiation therapy. Thus the authors recommend planned combined treatment for all resectable lesions.},
doi = {10.1002/1097-0142(19890615)63:12<2426::AID-CNCR2820631209>3.0.CO;2-K},
url = {https://www.osti.gov/biblio/5717504}, journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 63:12,
place = {United States},
year = {Thu Jun 15 00:00:00 EDT 1989},
month = {Thu Jun 15 00:00:00 EDT 1989}
}