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Title: Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model

Abstract

Infection with herpes simplex virus often results in a latent infection of local sensory ganglia and a disease characterized by periodic viral reactivation and mucocutaneous lesions. The factors that trigger reactivation in humans are still poorly defined. In our study, five patients with documented histories of recurrent herpes simplex virus infection on the buttocks or sacrum were exposed to three times their minimal erythema dose of ultraviolet light. Site-specific cutaneous herpes simplex virus infection occurred at 4.4 +/- 0.4 days after exposure to ultraviolet light in 8 of 13 attempts at reactivation. We conclude that ultraviolet light can reactivate herpes simplex virus under experimentally defined conditions. This model in humans should prove useful in evaluating the pathophysiology and prevention of viral reactivation.

Authors:
; ; ; ;
Publication Date:
Research Org.:
National Institute of Dental Research, Bethesda, MD
OSTI Identifier:
5717072
Resource Type:
Journal Article
Journal Name:
J. Am. Acad. Dermatol.; (United States)
Additional Journal Information:
Journal Volume: 17:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; VIRUSES; BIOLOGICAL RADIATION EFFECTS; INFECTIVITY; HERPES SIMPLEX; MAN; ULTRAVIOLET RADIATION; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; ELECTROMAGNETIC RADIATION; INFECTIOUS DISEASES; MAMMALS; MICROORGANISMS; PARASITES; PRIMATES; RADIATION EFFECTS; RADIATIONS; SKIN DISEASES; VERTEBRATES; VIRAL DISEASES; 560130* - Radiation Effects on Microorganisms

Citation Formats

Perna, J J, Mannix, M L, Rooney, J F, Notkins, A L, and Straus, S E. Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model. United States: N. p., 1987. Web. doi:10.1016/S0190-9622(87)70232-1.
Perna, J J, Mannix, M L, Rooney, J F, Notkins, A L, & Straus, S E. Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model. United States. https://doi.org/10.1016/S0190-9622(87)70232-1
Perna, J J, Mannix, M L, Rooney, J F, Notkins, A L, and Straus, S E. 1987. "Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model". United States. https://doi.org/10.1016/S0190-9622(87)70232-1.
@article{osti_5717072,
title = {Reactivation of latent herpes simplex virus infection by ultraviolet light: a human model},
author = {Perna, J J and Mannix, M L and Rooney, J F and Notkins, A L and Straus, S E},
abstractNote = {Infection with herpes simplex virus often results in a latent infection of local sensory ganglia and a disease characterized by periodic viral reactivation and mucocutaneous lesions. The factors that trigger reactivation in humans are still poorly defined. In our study, five patients with documented histories of recurrent herpes simplex virus infection on the buttocks or sacrum were exposed to three times their minimal erythema dose of ultraviolet light. Site-specific cutaneous herpes simplex virus infection occurred at 4.4 +/- 0.4 days after exposure to ultraviolet light in 8 of 13 attempts at reactivation. We conclude that ultraviolet light can reactivate herpes simplex virus under experimentally defined conditions. This model in humans should prove useful in evaluating the pathophysiology and prevention of viral reactivation.},
doi = {10.1016/S0190-9622(87)70232-1},
url = {https://www.osti.gov/biblio/5717072}, journal = {J. Am. Acad. Dermatol.; (United States)},
number = ,
volume = 17:3,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 1987},
month = {Tue Sep 01 00:00:00 EDT 1987}
}