Desmoid tumors: local control and patterns of relapse following radiation therapy

Conference · Mon Aug 01 00:00:00 EDT 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5714555

Leibel, S A; Wara, W M; Hill, D R; Bovill, Jr, E G; De Lorimier, A A; Beckstead, J H; Phillips, T L

Desmoid tumors are benign neoplasms, arising from musculoaponeurotic tissues, which tend to be locally infiltrative, resulting in a high rate of local recurrence following surgical resection. Nineteen patients with desmoid tumors underwent radiation therapy at the University of California, San Francisco, between 1970 and 1980. Fifteen patients were referred with local recurrence following one or more surgical resections. Three patients were referred for initial radiation therapy with unresectable tumors, and one patient received planned postoperative irradiation following subtotal tumor resection. At the time of treatment, 8 patients had nonresectable disease measuring greater than 10 cm. The majority of patients were treated to a tumor dose of 50 to 55 Gy at 1.6 to 1.8 Gy per fraction. With a median follow-up of 8 years, 13 patients remained free of recurrent disease following radiation therapy. Local control was not related to the amount of disease present at the time of treatment. Of the 6 patients who developed recurrent disease, only 1 patient had a true in-field recurrence. Four patients recurred at the margin of the radiation field 1 to 5 years following therapy. Moderate dose radiation therapy to desmoid tumors can result in lasting local control when surgical resection is not possible. Post operative radiation can improve the rate of local control for patients with a high risk of recurrence. As desmoid tumors tend to be locally infiltrative, fields must be very generous to prevent marginal recurrence. Systemic chemotherapy offers an alternative to ablative surgery in the event of local failure following radiation therapy.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5714555
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:8; Conference: 24. annual scientific meeting of the American Society of Therapeutic Radiologists, Orlando, FL, USA, 25 Oct 1982
• Country of Publication: United States
• Language: English

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