Circulating T-cell subsets in Graves' disease: differences between patients with active disease and in remission after /sup 131/I-therapy

Journal Article · Mon Aug 01 00:00:00 EDT 1983 · Clin. Immunol. Immunopathol.; (United States)

DOI:https://doi.org/10.1016/0090-1229(83)90160-5· OSTI ID:5714429

Canonica, G W; Bagnasco, M; Ferrini, S; Biassoni, P; Giordano, G; Corte, G

In the present investigation some surface markers in peripheral blood T lymphocytes of patients with active Graves' disease and subjects in remission after /sup 131/I-therapy have been studied. We confirmed low TG levels in untreated patients and normal values in treated subjects. Increased percentages of DR+, MLR4+ (activated T cells), and 5/9+ (inducer-helper) T cells were detected in patients with active disease, thus indicating the presence of activated T cells and suggesting increased levels of helper T cells. High percentages of MLR4+ and 5/9+, but normal levels of DR+ were found in /sup 131/I-treated subjects. The different distribution of DR and MLR4 positivities on 5/9+ and 5+9-T cells confirm the different meaning of these two markers of the activation state. The imbalance of T-cell subsets found in /sup 131/I-treated subjects and the normal values observed in patients with hyperthyroidism due to toxic adenoma indicate that hyperthyroidism per se is not sufficient to explain the T-cell alterations. The possible meaning of these findings is discussed with respect to previous hypotheses on the pathogenesis of Graves' disease.

• Research Organization: Cattedra di Endocrinologia, Genoa University, Italy
• OSTI ID: 5714429
• Journal Information: Clin. Immunol. Immunopathol.; (United States), Vol. 28:2
• Country of Publication: United States
• Language: English

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