Enhanced sensitivity of muscarinic cholinergic receptor associated with dopaminergic receptor subsensitivity after chronic antidepressant treatment

Journal Article · Mon Mar 09 00:00:00 EST 1981 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(81)90691-3· OSTI ID:5714169

Koide, T; Matsushita, H

The chronic effects of antidepressant treatment on striatal dopaminergic (DA) and muscarinic cholinergic (mACh) receptors of the rat brain have been examined comparatively in this study using /sup 3/H-spiroperidol (/sup 3/H-SPD) and /sup 3/H-quinuclidinyl benzilate (/sup 3/H-QNB) as the respective radioactive ligands. Imipramine and desipramine were used as prototype antidepressants. Although a single administration of imipramine or desipramine did not affect each receptor sensitivity, chronic treatment with each drug caused a supersensitivity of mACh receptor subsequent to DA receptor subsensitivity. Furthermore, it has been suggested that anti-mACh properties of imipramine or desipramine may not necessarily be related to the manifestation of mACh receptor supersensitivity and that sustained DA receptor subsensitivity may play some role in the alterations of mACh receptor sensitivity.

• Research Organization: Research Lab. of Chugai Pharmaceutical Co., Ltd., Tokyo, Japan
• OSTI ID: 5714169
• Journal Information: Life Sci.; (United States), Vol. 28:10
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
PSYCHOTROPIC DRUGS
BIOLOGICAL EFFECTS
CHRONIC INTAKE
RECEPTORS
SENSITIVITY
TRITIUM COMPOUNDS
UPTAKE
BRAIN
IMIPRAMINE
LIGANDS
RATS
AMINES
ANIMALS
ANTIDEPRESSANTS
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
INTAKE
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics