Radiolytic degradation scheme for 60Co-irradiated corticosteroids
The cobalt 60 radiolytic degradation products have been identified in the following corticosteroids: cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone sodium succinate, isoflupredone acetate, methylprednisolone, methylprednisolone acetate, prednisolone, prednisolone acetate, and prednisone. Two major types of degradation processes have been identified: loss of the corticoid side chain on the D-ring to produce the C-17 ketone and conversion of the C-11 alcohol, if present, to the C-11 ketone. Minor degradation products derived from other changes affecting the side chain are also identified in several corticosteroids. These compounds are frequently associated in corticosteroids as process impurities or degradation compounds. No new radiolytic compounds unique to 60Co-irradiation have been found. The majority of corticosteroids have been shown to be stable to 60Co-irradiation. The rates of radiolytic degradation ranged from 0.2 to 1.4%/Mrad.
- Research Organization:
- Control Analytical Research and Development, Upjohn Co., Kalamazoo, MI
- OSTI ID:
- 5708304
- Journal Information:
- J. Pharm. Sci.; (United States), Vol. 72:1
- Country of Publication:
- United States
- Language:
- English
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60 APPLIED LIFE SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CORTICOSTEROIDS
RADIOLYSIS
COBALT 60
CORTISONE
HYDROCORTISONE
PREDNISOLONE
PREDNISONE
STABILITY
ADRENAL HORMONES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COBALT ISOTOPES
DECOMPOSITION
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PREGNANES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIOISOTOPES
STEROID HORMONES
STEROIDS
YEARS LIVING RADIOISOTOPES
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