In-111-labeled leukocytes in the diagnosis of rejection and cytomegalovirus infection in renal transplant patients
Indium-111-labeled (In-111) leukocytes have been shown to be useful in the localization of inflammatory processes, including renal transplant rejection. Using previously reported labeling methods, 63 studies with this agent have been performed in 53 renal transplant patients. Indications for study included suspected rejection or cytomegalovirus (CMV) infection. Studies were performed in 33 men and 20 women, with ages ranging from 6 to 68 years. Autologous cells were normally used for labeling, although leukocytes obtained from ABO-compatible donors were used in three subjects. Rectilinear scanner and/or scintillation camera images were obtained at 24 hours after intravenous administration of 0.1 to 0.6 mCi of In-111-leukocytes. There was abnormal uptake of In-111-leukocytes in the transplanted kidney in 11 of 15 cases of rejection. In three additional cases of increased transplant uptake, CMV infection was present in two. Abnormal lung uptake was present in 13 of 14 patients with CMV infection. In four additional cases, increased lung uptake was associated with other pulmonary inflammatory disease. Increased lung activity was not seen in patients with uncomplicated transplant rejection. These results suggest that In-111-leukocyte imaging may be useful in the differential diagnosis of rejection versus CMV infection in renal transplant patients.
- OSTI ID:
- 5706550
- Journal Information:
- Clin. Nucl. Med.; (United States), Vol. 6:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
GRAFT-HOST REACTION
DIAGNOSIS
INDIUM 111
DIAGNOSTIC USES
KIDNEYS
SCINTISCANNING
VIRAL DISEASES
BIOLOGICAL LOCALIZATION
INFLAMMATION
LABELLED COMPOUNDS
LEUKOCYTES
LUNGS
PATIENTS
TRANSPLANTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SYMPTOMS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques