Cardiovascular stress of photochemotherapy (PUVA)

Journal Article · Sat Nov 01 00:00:00 EST 1980 · J. Am. Acad. Dermatol.; (United States)

DOI:https://doi.org/10.1016/S0190-9622(80)80116-2· OSTI ID:5705652

Ciafone, R A; Rhodes, A R; Audley, M; Freedberg, I M; Abelmann, W H

The recently devised therapy for psoriasis and related skin diseases, consisting of long-wave ultraviolet light and oral 8-methoxypsoralen (PUVA), was investigated for its cardiovascular effects. In seventeen patients, long-wave ultraviolet light therapy in a treatment enclosure (mean duration, 19.3 minutes) resulted in ambient temperatures of 39.2 degrees C +/- 2.1 degrees C (SD) and skin temperatures of 38.2 degrees C +/- 1.4 degrees C. In upright subjects, heart rate rose 30.8% to 114.4 +/- 25.2 beats per minute (bpm). Intensive room air conditioning, outside of the treatment enclosure, although significantly lowering skin and ambient temperatures, did not affect the heart rates significantly. PUVA therapy is associated with a definite cardiovascular stress when the box type of therapeutic unit is used. Possible modifications are discussed.

• OSTI ID: 5705652
• Journal Information: J. Am. Acad. Dermatol.; (United States), Vol. 3:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARDIOVASCULAR SYSTEM
BIOLOGICAL RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
BIOLOGICAL STRESS
BODY TEMPERATURE
PATIENTS
PSORALEN
PSORIASIS
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HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
SKIN DISEASES
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
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