Validity of estimates of myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography despite altered patterns of substrate utilization

Journal Article · Wed Feb 01 00:00:00 EST 1989 · J. Nucl. Med.; (United States)

OSTI ID:5701214

Brown, M A; Myears, D W; Bergmann, S R

We recently demonstrated that the myocardial turnover rate constant (k) measured noninvasively with positron emission tomography (PET) after intravenous administration of (/sup 11/C)acetate provides a reliable index of myocardial oxidative metabolism (MVO/sub 2/) theoretically independent of the pattern of myocardial substrate use. However, because estimates of metabolism with other metabolic tracers are sensitive to substrate use, we measured k in 12 dogs during baseline conditions and again after infusion of either glucose (n = 8) or Intralipid (n = 4), interventions that raised arterial glucose or fatty acids by more than fivefold with concomitant changes in myocardial substrate use. Following glucose administration k increased, but no difference was detected after compensation for changes in hemodynamics and myocardial work induced by the infusion (0.18 +/- 0.03 min-1) (t1/2 = 3.9 min) at baseline compared with 0.22 +/- 0.06 min-1 (t1/2 = 3.2 min, p = N.S.). k was not affected by Intralipid infusion (k = 0.15 +/- 0.06 min-1 at baseline and 0.14 +/- 0.04 min-1 during infusion), and correlated closely with MVO/sub 2/ measured directly (n = 19 comparisons, r = 0.89). The results indicate that estimates of MVO/sub 2/ using (/sup 11/C)acetate and PET are valid despite changes in the pattern of myocardial substrate utilization.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO (USA)
• OSTI ID: 5701214
• Journal Information: J. Nucl. Med.; (United States), Vol. 30:2
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
GLUCOSE
METABOLISM
MYOCARDIUM
POSITRON COMPUTED TOMOGRAPHY
ACETATES
CARBON 11
DOGS
OXYGEN
SUBSTRATES
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBON ISOTOPES
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEART
HEXOSES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
NONMETALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics