Induction of cytochrome p-450-ia1 in juvenile fish by creosote-contaminated sediment

Technical Report · Tue Jan 01 00:00:00 EST 1991

OSTI ID:5699928

Schoor, W P; Williams, D E; Takahashi, N

Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation.

• Research Organization: Environmental Protection Agency, Gulf Breeze, FL (United States). Environmental Research Lab.
• OSTI ID: 5699928
• Report Number(s): PB-92-129790/XAB
• Resource Relation: Other Information: Pub. in Archives of Environmental Contamination and Toxicology, v20 p497-504 1991. See also PB88-251699. Prepared in cooperation with Oregon State Univ., Corvallis. Dept. of Food Science and Technology
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CREOSOTE
TOXICITY
FISHES
SENSITIVITY
LIVER
PATHOLOGICAL CHANGES
SEDIMENTS
CONTAMINATION
CARCINOGENS
CELL PROLIFERATION
DRILL CORES
ENZYME INDUCTION
MIXED-FUNCTION OXIDASES
SIMULATION
WATER POLLUTION
ANIMALS
AQUATIC ORGANISMS
BODY
DIGESTIVE SYSTEM
ENZYMES
GENE REGULATION
GLANDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
POLLUTION
PROTEINS
VERTEBRATES
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology