Effects of fly ash inhalation on murine immune function: changes in macrophage-mediated activities

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90009-3· OSTI ID:5695843

Zarkower, A ^[1]; Eskew, M L; Scheuchenzuber, W J; Graham, J A

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1. Pennsylvania State Univ., University Park

Mice were exposed to fly ash particles (<2.1 ..mu..m diameter) by inhalation for variable amounts of time at concentrations ranging from 535 to 2221 ..mu..g/m/sup 3/. This fine fraction was approximately 32% by weight of the total dust generated. The effects of these exposures were assessed on macrophage-mediated functions. Phagocytosis of bacterial cells by the alveolar macrophages was depressed in the fly ash-exposed animals as was the ability to enhance T-cell mitogenesis. Fly ash exposure failed to produce a significant change in the cellular immune response (delayed-type hypersensitivity reaction) to antigenic challenge in the lungs of sensitized animals.

• OSTI ID: 5695843
• Journal Information: Environ. Res.; (United States), Vol. 29:1
• Country of Publication: United States
• Language: English

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