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Title: The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders

Abstract

The A1 allele of the Taq I polymorphism of the dopamine D{sub 2} receptor (DRD2) gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of controls. Other research has reported no significant difference in the prevalence of the A1 allele in alcoholics vs controls and no evidence that the DRD2 gene was linked to alcoholism. The authors hypothesized that these seemingly conflicting results might be because increases in the prevalence of the A1 allele may not be specific to alcoholism. Thus, they examined other disorders frequently associated with alcoholism or those believed to involve defects in dopaminergic neurotransmission.

Authors:
; ; ; ; ; ; ; ; ; ; ;  [1];  [2];  [3];  [4]; ;  [5];  [6]; ;  [7]
  1. City of Hope National Medical Center, Duarte, CA (United States)
  2. McLean Hospital, Belmont, MA (United States)
  3. Hillside Hospital, Glen Oaks, NY (United States)
  4. State Univ. of New York, Stony Brook (United States)
  5. Jerry L. Pettis Veterans Administration Hospital, Loma Linda, CA (United States)
  6. North Shore Univ. Hospital, Manhasset, NY (United States) Cornell Univ. Medical College, Manhasset, NY (United States)
  7. Veterans Administration Medical Center, Augusta, GA (United States)
Publication Date:
OSTI Identifier:
5687539
Resource Type:
Journal Article
Journal Name:
JAMA, Journal of the American Medical Association; (United States)
Additional Journal Information:
Journal Volume: 266:13; Journal ID: ISSN 0098-7484
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DOPAMINE; RECEPTORS; GENES; AUTORADIOGRAPHY; BIOELECTRICITY; DNA HYBRIDIZATION; HEREDITARY DISEASES; MAN; MENTAL DISORDERS; METABOLIC DISEASES; NERVE CELLS; RFLPS; AMINES; ANIMAL CELLS; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; CARDIOTONICS; CARDIOVASCULAR AGENTS; DISEASES; DRUGS; ELECTRICITY; HYBRIDIZATION; HYDROXY COMPOUNDS; MAMMALS; MEMBRANE PROTEINS; NEUROREGULATORS; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; PRIMATES; PROTEINS; SOMATIC CELLS; SYMPATHOMIMETICS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Comings, D E, Comings, B G, Muhleman, D, Dietz, G, Shahbahrami, B, Tast, D, Knell, E, Kocsis, P, Baumgarten, R, Kovacs, B W, Gysin, R, Flanagan, S D, Levy, D L, Smith, M, Klein, D N, MacMurray, J, Tosk, J M, Sverd, J, Borison, R L, and Evans, D D. The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders. United States: N. p., 1991. Web. doi:10.1001/jama.266.13.1793.
Comings, D E, Comings, B G, Muhleman, D, Dietz, G, Shahbahrami, B, Tast, D, Knell, E, Kocsis, P, Baumgarten, R, Kovacs, B W, Gysin, R, Flanagan, S D, Levy, D L, Smith, M, Klein, D N, MacMurray, J, Tosk, J M, Sverd, J, Borison, R L, & Evans, D D. The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders. United States. https://doi.org/10.1001/jama.266.13.1793
Comings, D E, Comings, B G, Muhleman, D, Dietz, G, Shahbahrami, B, Tast, D, Knell, E, Kocsis, P, Baumgarten, R, Kovacs, B W, Gysin, R, Flanagan, S D, Levy, D L, Smith, M, Klein, D N, MacMurray, J, Tosk, J M, Sverd, J, Borison, R L, and Evans, D D. 1991. "The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders". United States. https://doi.org/10.1001/jama.266.13.1793.
@article{osti_5687539,
title = {The dopamine D sub 2 receptor locus as a modifying gene in neuropsychiatric disorders},
author = {Comings, D E and Comings, B G and Muhleman, D and Dietz, G and Shahbahrami, B and Tast, D and Knell, E and Kocsis, P and Baumgarten, R and Kovacs, B W and Gysin, R and Flanagan, S D and Levy, D L and Smith, M and Klein, D N and MacMurray, J and Tosk, J M and Sverd, J and Borison, R L and Evans, D D},
abstractNote = {The A1 allele of the Taq I polymorphism of the dopamine D{sub 2} receptor (DRD2) gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of controls. Other research has reported no significant difference in the prevalence of the A1 allele in alcoholics vs controls and no evidence that the DRD2 gene was linked to alcoholism. The authors hypothesized that these seemingly conflicting results might be because increases in the prevalence of the A1 allele may not be specific to alcoholism. Thus, they examined other disorders frequently associated with alcoholism or those believed to involve defects in dopaminergic neurotransmission.},
doi = {10.1001/jama.266.13.1793},
url = {https://www.osti.gov/biblio/5687539}, journal = {JAMA, Journal of the American Medical Association; (United States)},
issn = {0098-7484},
number = ,
volume = 266:13,
place = {United States},
year = {Wed Oct 02 00:00:00 EDT 1991},
month = {Wed Oct 02 00:00:00 EDT 1991}
}