The effects of hyperthermia on normal mesenchymal tissues. Application of a histologic grading system

Journal Article · Wed Jun 01 00:00:00 EDT 1983 · Arch. Pathol. Lab. Med.; (United States)

OSTI ID:5681554

Meshorer, A; Prionas, S D; Fajardo, L F; Meyer, J L; Hahn, G M; Martinez, A A

The alterations produced by radiofrequency-induced hyperthermia of 42 to 48 degrees C for 30 minutes were studied in the subcutaneous adipose tissue and skeletal muscle of swine. Acute lesions (18 to 24 hours) included edema, hemorrhage, necrosis (predominantly of myocytes) and granulocytic exudate in fat or muscle. The most important chronic lesion (28 to 31 days) was fibrosis replacing either tissue. There was a histiolymphocytic exudate with foreign-body giant cells around large lipid vacuoles. Muscle necrosis persisted and there was variable myocyte regeneration. Several specimens showed deep necrosis and abscesses. A grading system was developed to quantitate independently acute and chronic damage in each tissue. Acute lesions were usually less severe and extensive than chronic ones, without obvious dose response. Chronic lesions showed clearly a dose response, which began at 43 degrees C and increased with temperature. The latter appear to be reliable indicators of hyperthermic damage in deep soft tissues.

• Research Organization: Department of Radiology, Stanford University School of Medicine, CA
• OSTI ID: 5681554
• Journal Information: Arch. Pathol. Lab. Med.; (United States), Vol. 107:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
TEMPERATURE EFFECTS
HYPERTHERMIA
BIOLOGICAL EFFECTS
MUSCLES
ABSCESSES
EDEMA
FIBROSIS
HEMORRHAGE
INJURIES
NECROSIS
SWINE
ANIMAL TISSUES
ANIMALS
BODY
BODY TEMPERATURE
CONNECTIVE TISSUE
DOMESTIC ANIMALS
MAMMALS
PATHOLOGICAL CHANGES
SYMPTOMS
TISSUES
VERTEBRATES
560205* - Thermal Effects- Vertebrates- (-1987)