Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18

Journal Article · Wed May 01 00:00:00 EDT 1985 · Arch. Gen. Psychiatr.; (United States)

DOI:https://doi.org/10.1001/archpsyc.1985.01790280019002· OSTI ID:5681291

Baxter, Jr, L R; Phelps, M E; Mazziotta, J C; Schwartz, J M; Gerner, R H; Selin, C E; Sumida, R M

Cerebral metabolic rates for glucose were examined in patients with unipolar depression (N = 11), bipolar depression (N = 5), mania (N = 5), bipolar mixed states (N = 3), and in normal controls (N = 9) using positron emission tomography and fluorodeoxyglucose F 18. All subjects were studied supine under ambient room conditions with eyes open. Bipolar depressed and mixed patients had supratentorial whole brain glucose metabolic rates that were significantly lower than those of the other comparison groups. The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state. Patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole, when compared with normal controls and patients with bipolar depression.

• OSTI ID: 5681291
• Journal Information: Arch. Gen. Psychiatr.; (United States), Vol. 42:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
EMISSION COMPUTED TOMOGRAPHY
GLUCOSE
METABOLISM
COMPARATIVE EVALUATIONS
MENTAL DISORDERS
PATIENTS
ALDEHYDES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
HEXOSES
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
SACCHARIDES
TOMOGRAPHY
550501* - Metabolism- Tracer Techniques