Cytogenetic effects of alachlor and/or atrazine in vivo and in vitro
- Univ. of Wisconsin, Madison (United States)
- Risk Writers, Ltd., Minneapolis, MN (United States)
The purpose of this study was to assess the cytogenetic effects of two commonly used herbicides, alachlor and atrazine, which are often found together in groundwater. Chromosome damage was examined in bone marrow cells of mice drinking water containing 20 ppm alachlor and/or 20 ppm atrazine, with an immunosuppressive dose of cyclophosphamide used as a positive control. Chromosome damage was also quantified in human lymphocytes. The in vitro study demonstrated dose related cytogenetic damage not associated with mitotic inhibition or cell death, with damage due to the alachlor-atrazine combination suggesting an additive model. The fact that the elevated mitotic index was associated with immune suppresion in the cyclophosphamide group suggests that death of cells with accumulated chromosomal aberrations resulted in increased bone marrow proliferation, so a higher fraction of cells examined were newer with less damage.
- OSTI ID:
- 5677791
- Journal Information:
- Environmental and Molecular Mutagenesis; (United States), Vol. 19:1; ISSN 0893-6692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
HERBICIDES
GENETIC EFFECTS
AZINES
LYMPHOCYTES
MICE
MUTAGEN SCREENING
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PESTICIDES
RODENTS
SCREENING
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology