Chromosomal abnormalities in human sperm
The ability to analyze human sperm chromosome complements after penetration of zona pellucida-free hamster eggs provides the first opportunity to study the frequency and type of chromosomal abnormalities in human gametes. Two large-scale studies have provided information on normal men. We have studied 1,426 sperm complements from 45 normal men and found an abnormality rate of 8.9%. Brandriff et al. (5) found 8.1% abnormal complements in 909 sperm from 4 men. The distribution of numerical and structural abnormalities was markedly dissimilar in the 2 studies. The frequency of aneuploidy was 5% in our sample and only 1.6% in Brandriff's, perhaps reflecting individual variability among donors. The frequency of 24,YY sperm was low: 0/1,426 and 1/909. This suggests that the estimates of nondisjunction based on fluorescent Y body data (1% to 5%) are not accurate. We have also studied men at increased risk of sperm chromosomal abnormalities. The frequency of chromosomally unbalanced sperm in 6 men heterozygous for structural abnormalities varied dramatically: 77% for t11;22, 32% for t6;14, 19% for t5;18, 13% for t14;21, and 0% for inv 3 and 7. We have also studied 13 cancer patients before and after radiotherapy and demonstrated a significant dose-dependent increase of sperm chromosome abnormalities (numerical and structural) 36 months after radiation treatment.
- Research Organization:
- Univ. of Calgary, Alberta
- OSTI ID:
- 5675602
- Journal Information:
- Basic Life Sci.; (United States), Journal Name: Basic Life Sci.; (United States)
- Country of Publication:
- United States
- Language:
- English
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RADIOTHERAPY
SIDE EFFECTS
SPERMATOZOA
CHROMOSOMAL ABERRATIONS
ANEUPLOIDY
GENETIC RADIATION EFFECTS
HETEROCHROMATIN
MEN
NEOPLASMS
OOCYTES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMATIN
DISEASES
GAMETES
GENETIC EFFECTS
GERM CELLS
MALES
MAMMALS
MAN
MEDICINE
MUTATIONS
NUCLEAR MEDICINE
PLOIDY
PRIMATES
RADIATION EFFECTS
RADIOLOGY
THERAPY
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560151* - Radiation Effects on Animals- Man