Macrophage depletion of mouse lung following inhalation of /sup 238/PuO/sub 2/
Changes in the free-cell population of the lungs of two strains of mice (SAS/4 and CBA/H) were studied up to 4 months after inhalation exposure to a sized fraction of /sup 239/PuO/sub 2/ particles (1.5 micron AMAD) to give initial alveolar depositions (IADs) ranging from 17 to 810 Bq. A sample of the free-cell population of the lung was recovered by bronchoalveolar lavage, and a radiometric method was used to estimate the total number of pulmonary alveolar macrophages (PAM) in the lung. The response of the lung to /sup 239/PuO/sub 2/ was characterized by an initial, dose-dependent depression in the total number of PAM following an IAD as low as 50 Bq. At IADs greater than 150 Bq, the initial depression continued for longer, merging into a chronic phase in which the PAM were larger and were accompanied by a minor infiltration of leukocytes. These findings were confirmed by histology, which also revealed focal accumulations of Type II pneumocytes. The results indicate that inhaled alpha-emitting particles are effective at producing a depletion in the alveolar macrophage population at relatively low IADs and that chronic effects on the cells can be produced by higher concentrations.
- Research Organization:
- Inhalation Toxicology Group, Harwell, England
- OSTI ID:
- 5675185
- Journal Information:
- Radiat. Res.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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LUNGS
BIOLOGICAL RADIATION EFFECTS
MACROPHAGES
INHIBITION
PLUTONIUM 239
INHALATION
AEROSOLS
DOSE-RESPONSE RELATIONSHIPS
LAVAGE
MICE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTAKE
ISOTOPES
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PHAGOCYTES
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RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
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SOLS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
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& Cells