Ontogeny of somatostatin receptors in the rat somatosensory cortex

Journal Article · Fri Mar 08 00:00:00 EST 1991 · Journal of Comparative Neurology; (USA)

DOI:https://doi.org/10.1002/cne.903050202· OSTI ID:5671615

Gonzalez, B J; Leroux, P; Bodenant, C; Vaudry, H ^[1]

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1. Groupe de Recherche en Endocrinologie Moleculaire, CNRS URA 650, Unite Affiliee a l'INSERM, Mont-Saint-Aignan, (France)

The distribution and density of SRIF receptors (SRIF-R) were studied during development in the rat somatosensory cortex by in vitro autoradiography with monoiodinated (Tyr0-DTrp8)S14. In 16-day-old fetuses (E16), intense labeling was evident in the intermediate zone of the cortex while low concentrations of SRIF-R were detected in the marginal and ventricular zones. The highest density of SRIF-R was measured in the intermediate zone at E18. At this stage, labeling was also intense in the internal part of the developing cortical plate; in contrast, the concentration of binding sites associated with the marginal and ventricular zones remained relatively low. Profound modifications in the distribution of SRIF-R appeared at birth. In particular, a transient reduction of receptor density occurred in the cortical plate. During the first postnatal week, the density of receptors measured in the intermediate zone decreased gradually; conversely, high levels of SRIF-R were observed in the developing cortical layers (II to VI). At postpartum day 13 (P13), a stage which just precedes completion of cell migration in the parietal cortex, the most intensely labeled regions were layers V-VI and future layers II-III. From P13 to adulthood, the concentrations of SRIF-R decreased in all cortical layers (I to VI) and the pattern of distribution of receptors at P21 was similar to that observed in the adults.

• OSTI ID: 5671615
• Journal Information: Journal of Comparative Neurology; (USA), Vol. 305:2; ISSN 0021-9967
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CEREBRAL CORTEX
ONTOGENESIS
RECEPTORS
TISSUE DISTRIBUTION
SOMATOSTATIN
AGE DEPENDENCE
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
FETUSES
IODINE ISOTOPES
RATS
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
DISTRIBUTION
ISOTOPES
KINETICS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques