Determination of the atherogenic potential of inhaled carbon monoxide. Research report, October 1986-December 1991
The effects of chronic exposure to moderate levels of carbon monoxide upon the augmentation of arteriosclerotic plaque development were investigated in a series of in vivo studies in the cockerel (young rooster). Three questions were posed: (1) Will inhaled carbon monoxide at levels of 50 to 200 parts per million (ppm) (two hours/day for 16 weeks) be sufficient to augment arteriosclerotic plaque-promoting agent. (2) Will the inhalation of 100 ppm carbon monoxide (two hours/day for 16 weeks), concomitant with the feeding of low levels (0.1%) of cholesterol, yield larger plaques than those obtained with either of these agents administered alone. (3) Will inhalation of 100 ppm carbon monoxide (two hours/day for 11 or 22 weeks), by cockerels in whom plaques have already appeared, further augment plaque development. Chronic inhalation of carbon monoxide at levels as high as 200 ppm did not affect augmentation of arteriosclerotic plaque development. When administered at the same time that plaque development was being promoted by cholesterol feeding, carbon monoxide had no further effect upon plaque development. When administered after either carcinogen-associated or diet-augmented increases in plaque size, carbon monoxide did not elicit further increases in plaque size.
- Research Organization:
- New York Univ., NY (United States). Inst. of Environmental Medicine
- OSTI ID:
- 5671040
- Report Number(s):
- PB-94-122090/XAB
- Country of Publication:
- United States
- Language:
- English
Similar Records
Determination of the atherogenic potential of inhaled carbon monoxide
Cigarette smoke and carbon monoxide do not have equivalent effects upon development of arteriosclerotic lesions